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Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.574

2009

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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (13), p.5161-5166

2006

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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (25), p.8754-8759

2008

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Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (18), p.8457-8462

2010

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Abnormal Dendritic Spines in Fragile X Knockout Mice: Maturation and Pruning Deficits

Proceedings of the National Academy of Sciences - PNAS, 1997-05, Vol.94 (10), p.5401-5404

1997

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Identification of a series of benzoxazoles as potent 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1115-1117

2009

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A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

Pharmacology & therapeutics (Oxford), 2009-06, Vol.122 (3), p.302-311

2009

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Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

The Journal of neuroscience, 1996-07, Vol.16 (14), p.4529-4535

1996

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ApoE Promotes the Proteolytic Degradation of Aβ

Neuron (Cambridge, Mass.), 2008-06, Vol.58 (5), p.681-693

2008

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A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

Pharmacology & therapeutics (Oxford), 2009-06, Vol.122 (3), p.302-311

2009

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Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.134

2008

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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific

The Journal of neuroscience, 2012-02, Vol.32 (8), p.2696-2702

2012

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Metabolism of a 5HT6 antagonist, 2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole (SAM-760): impact of sulfonamide metabolism on diminution of a ketoconazole mediated clinical drug-drug interaction

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.934-942

2018

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Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

European journal of medicinal chemistry, 2014-05, Vol.78, p.401-418

2014

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The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

Molecular and cellular neuroscience, 2007-04, Vol.34 (4), p.621-628

2007

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease

The Journal of neuroscience, 2005-09, Vol.25 (39), p.8898-8902

2005

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The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test

Behavioural brain research, 2008-04, Vol.188 (2), p.412-415

2008

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5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7639-7646

2010

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SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (14), p.5247-5258

2009

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N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10277-10281

2012

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Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

The Journal of biological chemistry, 2010-01, Vol.285 (5), p.3417-3427

2010

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2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2452-2468

2012

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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

Psychopharmacologia, 2011-12, Vol.218 (4), p.635-647

2011

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Fragile X Mental Retardation Protein is Translated near Synapses in Response to Neurotransmitter Activation

Proceedings of the National Academy of Sciences - PNAS, 1997-05, Vol.94 (10), p.5395-5400

1997

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Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia

Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes

Abnormal Dendritic Spines in Fragile X Knockout Mice: Maturation and Pruning Deficits

Identification of a series of benzoxazoles as potent 5-HT6 ligands

A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

ApoE Promotes the Proteolytic Degradation of Aβ

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific

Metabolism of a 5HT6 antagonist, 2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole (SAM-760): impact of sulfonamide metabolism on diminution of a ketoconazole mediated clinical drug-drug interaction

Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease

The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test

5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists

Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

Fragile X Mental Retardation Protein is Translated near Synapses in Response to Neurotransmitter Activation

Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

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