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Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

Scientific reports, 2020-02, Vol.10 (1), p.3374-3374, Article 3374

2020

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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005976-e1005976

2016

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Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1571

2020

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THC shows activity against cultured Plasmodium falciparum

Bioorganic & medicinal chemistry letters, 2021-12, Vol.54, p.128442-128442, Article 128442

2021

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A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

mBio, 2017-05, Vol.8 (3)

2017

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Insights into the Role of Heme in the Mechanism of Action of Antimalarials

ACS chemical biology, 2013-01, Vol.8 (1), p.133-137

2013

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Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites

European journal of medicinal chemistry, 2018-11, Vol.159, p.243-254

2018

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Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6512-6530

2016

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Subcellular Localisation of a Quinoline-Containing Fluorescent Cyclometallated Ir III Complex in Plasmodium falciparum

Chembiochem : a European journal of chemical biology, 2021-05, Vol.22 (9), p.1568-1572

2021

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The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis

Scientific reports, 2024-01, Vol.14 (1), p.2463-2463, Article 2463

2024

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Subcellular Localisation of a Quinoline‐Containing Fluorescent Cyclometallated IrIII Complex in Plasmodium falciparum

Chembiochem : a European journal of chemical biology, 2021-05, Vol.22 (9), p.1568-1572

2021

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Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

Malaria journal, 2015-06, Vol.14 (1), p.253, Article 253

2015

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Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (16), p.5210-5217

2015

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A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes

ACS infectious diseases, 2021-02, Vol.7 (2), p.362-376

2021

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Fate of haem iron in the malaria parasite Plasmodium falciparum

Biochemical journal, 2002-07, Vol.365 (Pt 2), p.343-347

2002

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Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.201-205

2017

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Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

Nature microbiology, 2017-10, Vol.2 (10), p.1403

2017

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Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights

Journal of organometallic chemistry, 2022-09, Vol.975, p.122419, Article 122419

2022

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Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes

European journal of medicinal chemistry, 2020-11, Vol.206, p.112694-112694, Article 112694

2020

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Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents

European journal of medicinal chemistry, 2020-07, Vol.198, p.112330, Article 112330

2020

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Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

European journal of medicinal chemistry, 2020-02, Vol.187, p.111963-111963, Article 111963

2020

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Rifampicin and protein concentrations in paired spinal versus ventricular cerebrospinal fluid samples of children with tuberculous meningitis

Journal of antimicrobial chemotherapy, 2024-02, Vol.79 (2), p.280-286

2024

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Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates

European journal of medicinal chemistry, 2024-01, Vol.264, p.115969-115969, Article 115969

2024

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Synthesis, characterization and pharmacological evaluation of ferrocenyl azines and their rhodium(I) complexes

Journal of organometallic chemistry, 2015-07, Vol.788, p.1-8

2015

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Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin

European journal of medicinal chemistry, 2016-10, Vol.122, p.635-646

2016

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Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

THC shows activity against cultured Plasmodium falciparum

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

Subcellular Localisation of a Quinoline-Containing Fluorescent Cyclometallated Ir III Complex in Plasmodium falciparum

The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis

Subcellular Localisation of a Quinoline‐Containing Fluorescent Cyclometallated IrIII Complex in Plasmodium falciparum

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes

Fate of haem iron in the malaria parasite Plasmodium falciparum

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights

Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes

Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

Rifampicin and protein concentrations in paired spinal versus ventricular cerebrospinal fluid samples of children with tuberculous meningitis

Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates

Synthesis, characterization and pharmacological evaluation of ferrocenyl azines and their rhodium(I) complexes

Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin

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