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Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury

The Journal of biological chemistry, 2002-08, Vol.277 (33), p.30128-30136

2002

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Total Synthesis of Ionomycin Using Ring-Opening Strategies

Organic letters, 2002-05, Vol.4 (11), p.1879-1882

2002

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

The Journal of experimental medicine, 2004-01, Vol.199 (2), p.199-207

2004

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Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3760-3763

2010

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A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

The Journal of biological chemistry, 2004-07, Vol.279 (27), p.27905-27914

2004

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Diastereoselective Intermolecular [4 + 3] Cycloadditions via an Extended Transition State: A Route to Enantiomerically Enriched Cycloadducts

Journal of the American Chemical Society, 1996-11, Vol.118 (44), p.10930-10931

1996

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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3200-3205

2008

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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.288-293

2011

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'lt's important that their styles are a good ?t'

Journal of Accountancy, 2020-11, Vol.230 (5), p.72-72

Colucci, John

2020

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New indole amide derivatives as potent CRTH2 receptor antagonists

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3471-3474

2011

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A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.484-487

2011

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Total synthesis of (+)-ambruticin S

Tetrahedron, 2003-08, Vol.59 (35), p.6819-6832

2003

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Neuroprotective effects of M826, a reversible caspase‐3 inhibitor, in the rat malonate model of Huntington's disease

British journal of pharmacology, 2004-02, Vol.141 (4), p.689-697

2004

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Total Synthesis of (+)-Ambruticin S

Journal of the American Chemical Society, 2001-12, Vol.123 (49), p.12432-12433

2001

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP₄ receptor

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.1041-1046

2011

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP sub(4) receptor

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.1041-1046

2011

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Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1173-1180

2005

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP 4 receptor

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (3), p.1041-1046

2011

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.2048-2054

2008

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Discovery of Mix-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (1), p.288-293

2011

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP sub(4) receptor

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2048-2054

2008

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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1671-1674

2007

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Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (6), p.2048-2054

2008

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Investigation of the Diastereoselective Cyclization of Bis-sulfonyl Esters

Organic letters, 2002-12, Vol.4 (26), p.4705-4708

2002

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Benign Breast Conditions and Disease

Family Medicine, 2022, p.1507-1521

2022

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Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury

Total Synthesis of Ionomycin Using Ring-Opening Strategies

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

Diastereoselective Intermolecular [4 + 3] Cycloadditions via an Extended Transition State: A Route to Enantiomerically Enriched Cycloadducts

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

'lt's important that their styles are a good ?t'

New indole amide derivatives as potent CRTH2 receptor antagonists

A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

Total synthesis of (+)-ambruticin S

Neuroprotective effects of M826, a reversible caspase‐3 inhibitor, in the rat malonate model of Huntington's disease

Total Synthesis of (+)-Ambruticin S

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP₄ receptor

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP sub(4) receptor

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP 4 receptor

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Discovery of Mix-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP sub(4) receptor

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor

Investigation of the Diastereoselective Cyclization of Bis-sulfonyl Esters

Benign Breast Conditions and Disease

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