UB Paderborn / Katalog / Suche / in CDI

HTS and hit finding in academia – from chemical genomics to drug discovery

Drug discovery today, 2009-12, Vol.14 (23-24), p.1150-1158

2009

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Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4541-4559

2024

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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8896-8916

2023

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Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1962-1967

2019

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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4454-4465

2009

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Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Journal of medicinal chemistry, 2015-10, Vol.58 (19), p.7695-7706

2015

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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

ChemMedChem, 2015-11, Vol.10 (11), p.1821-1836

2015

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Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

ChemMedChem, 2011-12, Vol.6 (12), p.2214-2224

2011

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A Novel Allosteric Inhibitor of the Uridine Diphosphate N‑Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

ACS chemical biology, 2013-09, Vol.8 (9), p.1981-1987

2013

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High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei

Eukaryotic Cell, 2014-03, Vol.13 (3), p.412-426

2014

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Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

ChemMedChem, 2011-02, Vol.6 (2), p.302-308

2011

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Quinol derivatives as potential trypanocidal agents

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (4), p.1607-1615

2012

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Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)

ChemMedChem, 2015-11, Vol.10 (11), p.1769-1769

2015

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The First Potent and Selective Inhibitors of the Glycine Transporter Type 2

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2679-2682

2001

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Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

ChemMedChem, 2011-10, Vol.6 (10), p.1832-1840

2011

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8374-8389

2018

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Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6814-6826

2021

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Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)

ChemMedChem, 2011-02, Vol.6 (2), p.209-209

2011

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SerpinB3, a new prognostic tool in breast cancer patients treated with neoadjuvant chemotherapy

Breast cancer research and treatment, 2012-04, Vol.132 (3), p.807-818

2012

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Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Cellular and molecular gastroenterology and hepatology, 2023-01, Vol.16 (3), p.431-450

2023

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O-35 serpinB3, a biomarker of taxane benefit in breast cancer

European journal of cancer supplements, 2010-09, Vol.8 (6), p.13-13

2010

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HTS and hit finding in academia – from chemical genomics to drug discovery

Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

A Novel Allosteric Inhibitor of the Uridine Diphosphate N‑Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

Quinol derivatives as potential trypanocidal agents

Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)

The First Potent and Selective Inhibitors of the Glycine Transporter Type 2

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

SerpinB3, a new prognostic tool in breast cancer patients treated with neoadjuvant chemotherapy

Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

O-35 serpinB3, a biomarker of taxane benefit in breast cancer

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