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68 Leveraging Probability Theory and Machine Learning to Reduce Diagnostic Uncertainty

Annals of emergency medicine, 2024-10, Vol.84 (4), p.S32-S33

2024

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240 Is Multidisciplinary Checklist Utilization Associated With Guideline Adherence or Mortality in Patients With Severe Sepsis?

Annals of emergency medicine, 2020-10, Vol.76 (4), p.S93-S93

2020

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116 The Effect of a Physician in Triage on Number of Orders Placed

Annals of emergency medicine, 2019-10, Vol.74 (4), p.S47-S47

2019

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Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

Cancer research (Chicago, Ill.), 2017-05, Vol.77 (9), p.2512-2521

2017

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Machine learning approaches and databases for prediction of drug–target interaction: a survey paper

Briefings in bioinformatics, 2021-01, Vol.22 (1), p.247-269

2021

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Structural studies of intrinsically disordered MLL‐fusion protein AF9 in complex with peptidomimetic inhibitors

Protein science, 2024-06, Vol.33 (6), p.e5019-n/a

2024

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FBW7 -Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

Molecular cancer therapeutics, 2017-09, Vol.16 (9), p.1979-1988

2017

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Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins

Cancer research (Chicago, Ill.), 2018-08, Vol.78 (16), p.4704-4715

2018

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Abstract IA016: Characterization of the protein-protein interactions involved in hDOT1L epigenetic regulation on biochemical, structural and functional level towards developing new therapeutic intervention

Cancer research (Chicago, Ill.), 2022-12, Vol.82 (23_Supplement_2), p.IA016-IA016

Nikolovska-Coleska, Zaneta

2022

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Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Journal of the American Chemical Society, 2005-07, Vol.127 (29), p.10130-10131

2005

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p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Nature communications, 2018-07, Vol.9 (1), p.2801-13, Article 2801

2018

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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

Molecular cancer therapeutics, 2014-03, Vol.13 (3), p.565-575

2014

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A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

Journal of medicinal chemistry, 2011-04, Vol.54 (8), p.2714-2726

2011

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Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review

Expert opinion on therapeutic patents, 2012-01, Vol.22 (1), p.37-55

2012

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Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Leukemia, 2015-06, Vol.29 (6), p.1290-1300

2015

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Analytical biochemistry, 2004-09, Vol.332 (2), p.261-273

2004

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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3432-3435

2006

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (10), p.3933-3938

2008

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Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1137-1146

2012

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3‑Substituted‑N‑(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl‑1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.4111-4133

2014

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Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7970-7973

2009

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HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?

Antiviral research, 2019-03, Vol.163, p.82-90

2019

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Managing opioid waste, cost, and opportunity for drug diversion in the emergency department

The American journal of emergency medicine, 2023-07, Vol.69, p.195-199

2023

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Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

Cancers, 2021-02, Vol.13 (4), p.642

2021

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Studying protein-protein interactions using surface plasmon resonance

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1278, p.109

Nikolovska-Coleska, Zaneta

2015

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68 Leveraging Probability Theory and Machine Learning to Reduce Diagnostic Uncertainty

240 Is Multidisciplinary Checklist Utilization Associated With Guideline Adherence or Mortality in Patients With Severe Sepsis?

116 The Effect of a Physician in Triage on Number of Orders Placed

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

Machine learning approaches and databases for prediction of drug–target interaction: a survey paper

Structural studies of intrinsically disordered MLL‐fusion protein AF9 in complex with peptidomimetic inhibitors

FBW7 -Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins

Abstract IA016: Characterization of the protein-protein interactions involved in hDOT1L epigenetic regulation on biochemical, structural and functional level towards developing new therapeutic intervention

Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

3‑Substituted‑N‑(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl‑1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?

Managing opioid waste, cost, and opportunity for drug diversion in the emergency department

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

Studying protein-protein interactions using surface plasmon resonance

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