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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (26), p.7124-7129

2016

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.583-598

2018

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PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation

Frontiers in oncology, 2024-05, Vol.14, p.1380633-1380633

2024

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Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target Proteins

Annual review of cancer biology, 2018-03, Vol.2 (1), p.41-58

2018

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

Genes & development, 2003-06, Vol.17 (11), p.1352-1365

2003

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Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

Leukemia, 2018-10, Vol.32 (10), p.2224-2239

2018

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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

The Journal of clinical investigation, 2003-07, Vol.112 (2), p.197-208

2003

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Abstract 2379: Elaborating the mechanism of PARP synthetic lethality in ATM loss

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2379-2379

2020

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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

Cancer research (Chicago, Ill.), 2007-10, Vol.67 (20), p.9887-9893

2007

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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

Leukemia, 2017-09, Vol.31 (9), p.1951-1961

2017

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Expression of engrailed proteins in arthropods, annelids, and chordates

Cell, 1989-09, Vol.58 (5), p.955-968

1989

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Abstract A091: Targeting homologous recombination repair defects in lung cancer

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.A091-A091

2019

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Abstract 3242: Triple checkpoint blockade targeting PD-1, TIM-3, and LAG-3 reinvigorates ovarian cancer-infiltrating T cells by increasing T cell polyfunctionality and effector function

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3242-3242

2019

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Identification of CDK4 Sequences Involved in Cyclin D1 and p16 Binding

The Journal of biological chemistry, 1997-07, Vol.272 (30), p.18869-18874

1997

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Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function

Protein expression and purification, 2005-12, Vol.44 (2), p.121-129

2005

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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

The Journal of clinical investigation, 2003-07, Vol.112 (2), p.197-208

2003

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Abstract 6175: CDK8 inhibition potentiates the efficacy of niraparib in homologous recombination proficient cancer cell lines

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6175-6175

2023

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Abstract 5067: BET protein proteolysis targeting chimera (BETP-PROTACs) exert more potent activity than BETP bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm (MPN) secondary (s) AML cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5067-5067

2017

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Temperature-sensitive lethal mutations on yeast chromosome I appear to define only a small number of genes [Saccharomyces cerevisiae]

Genetics (Austin), 1984-09, Vol.108 (1), p.67-90

1984

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Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene

Cell, 1985-01, Vol.43 (1), p.29-37

1985

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Chapter 17. Chemical Inhibitors of Cyclin-dependent Kinases

Annual Reports in Medicinal Chemistry, 1997, Vol.32, p.171-179

1997

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Expert systems development standards

Expert systems with applications, 1991, Vol.2 (4), p.239-243

1991

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Neural networks: a high impact technology with applications in telecommunications

IEEE Global Telecommunications Conference GLOBECOM '91: Countdown to the New Millennium. Conference Record, 1991, p.1038-1042 vol.2

Coleman, K.G.

1991

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Molecular Cloning of Chromosome I DNA from Saccharomyces cerevisiae: Isolation and Characterization of the CDC24 Gene and Adjacent Regions of the Chromosome

Molecular and cellular biology, 1986-12, Vol.6 (12), p.4516-4525

1986

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation

Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target Proteins

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621

Abstract 2379: Elaborating the mechanism of PARP synthetic lethality in ATM loss

Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

Expression of engrailed proteins in arthropods, annelids, and chordates

Abstract A091: Targeting homologous recombination repair defects in lung cancer

Abstract 3242: Triple checkpoint blockade targeting PD-1, TIM-3, and LAG-3 reinvigorates ovarian cancer-infiltrating T cells by increasing T cell polyfunctionality and effector function

Identification of CDK4 Sequences Involved in Cyclin D1 and p16 Binding

Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Abstract 6175: CDK8 inhibition potentiates the efficacy of niraparib in homologous recombination proficient cancer cell lines

Abstract 5067: BET protein proteolysis targeting chimera (BETP-PROTACs) exert more potent activity than BETP bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm (MPN) secondary (s) AML cells

Temperature-sensitive lethal mutations on yeast chromosome I appear to define only a small number of genes [Saccharomyces cerevisiae]

Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene

Chapter 17. Chemical Inhibitors of Cyclin-dependent Kinases

Expert systems development standards

Neural networks: a high impact technology with applications in telecommunications

Molecular Cloning of Chromosome I DNA from Saccharomyces cerevisiae: Isolation and Characterization of the CDC24 Gene and Adjacent Regions of the Chromosome

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