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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.15-20

2016

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Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Frontiers in physiology, 2017-08, Vol.8, p.616-616

2017

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Journal of biomolecular screening, 2016-01, Vol.21 (1), p.1-11

2016

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Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs

Regulatory toxicology and pharmacology, 2011-04, Vol.59 (3), p.385-390

2011

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Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

Frontiers in physiology, 2017-11, Vol.8, p.917-917

2017

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Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury

Toxicologic Pathology, 2010-10, Vol.38 (6), p.856-871

2010

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EADB: an estrogenic activity database for assessing potential endocrine activity

Toxicological sciences, 2013-10, Vol.135 (2), p.277-291

2013

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Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Frontiers in physiology, 2017-12, Vol.8, p.1025-1025

2017

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Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate : implications for gene-specific therapy

Circulation (New York, N.Y.), 1995-12, Vol.92 (12), p.3381-3386

1995

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Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

Circulation. Arrhythmia and electrophysiology, 2017-02, Vol.10 (2), p.e004628-e004628

2017

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Inhibition of Cardiac Delayed Rectifier K+ Current by Overexpression of the Long-QT Syndrome HERG G628S Mutation in Transgenic Mice

Circulation research, 1998-09, Vol.83 (6), p.668-678

1998

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Reassessing the validity of surrogate markers of drug efficacy in the treatment of coronary artery disease

Current opinion in investigational drugs (London, England : 2000), 2009-03, Vol.10 (3), p.239

Colatsky, Thomas J

2009

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'Impedance matching' of data sets in biomarker research

Current opinion in investigational drugs (London, England : 2000), 2010-03, Vol.11 (3), p.262

Colatsky, Thomas J

2010

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A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.233-239

2016

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A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification

Emerging therapeutic targets, 2000-02, Vol.4 (1), p.39-49

2000

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What happens when cardiac Na channels lose their function? 1 - Numerical studies of the vulnerable period in tissue expressing mutant channels

Cardiovascular research, 2003, Vol.57 (1), p.82-91

2003

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Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity

Journal of pharmacological and toxicological methods, 2017-11, Vol.88 (Pt 2), p.109-122

2017

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Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine

Xenobiotica, 2017-05, Vol.47 (5), p.431-438

2017

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Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1

Toxicologic pathology, 2015-07, Vol.43 (5), p.662-674

2015

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Metabolomics data and the biomarker qualification process

Metabolomics, 2012-02, Vol.8 (1), p.2-7

2012

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Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1410

1999

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Emerging Technologies and their Role in Regulatory Review

Drug Discovery Toxicology, 2016, p.1-11

2016

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Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats

Toxicology letters, 2012-09, Vol.213 (2), p.285-291

2012

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Metabolic profiling and biomarker discovery

Current opinion in investigational drugs (London, England : 2000), 2003-03, Vol.4 (3), p.262

2003

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Ion Channels: Too Complex for Rational Drug Design?

Neuron, 1996-05, Vol.16 (5), p.913-919

1996

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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury

EADB: an estrogenic activity database for assessing potential endocrine activity

Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate : implications for gene-specific therapy

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

Inhibition of Cardiac Delayed Rectifier K+ Current by Overexpression of the Long-QT Syndrome HERG G628S Mutation in Transgenic Mice

Reassessing the validity of surrogate markers of drug efficacy in the treatment of coronary artery disease

'Impedance matching' of data sets in biomarker research

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification

What happens when cardiac Na channels lose their function? 1 - Numerical studies of the vulnerable period in tissue expressing mutant channels

Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity

Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine

Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1

Metabolomics data and the biomarker qualification process

Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat

Emerging Technologies and their Role in Regulatory Review

Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats

Metabolic profiling and biomarker discovery

Ion Channels: Too Complex for Rational Drug Design?

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