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Small-molecule targeting of brachyury transcription factor addiction in chordoma

Nature medicine, 2019-02, Vol.25 (2), p.292-300

2019

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Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK

Genes & development, 2008-06, Vol.22 (11), p.1490-1500

2008

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The driver landscape of sporadic chordoma

Nature communications, 2017-10, Vol.8 (1), p.890-6, Article 890

2017

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Glycogen Synthase Kinase 3β Functions To Specify Gene-Specific, NF-κB-Dependent Transcription

Molecular and Cellular Biology, 2005-10, Vol.25 (19), p.8444-8455

2005

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A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

Nature (London), 2003-06, Vol.423 (6940), p.659-663

2003

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IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

Oncotarget, 2016-10, Vol.7 (43), p.69173-69187

2016

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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

Genes & development, 2004-12, Vol.18 (23), p.2905-2915

2004

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Selective activation of NF-κB subunits in human breast cancer : potential roles for NF-κB2/p52 and for Bcl-3

Oncogene, 2000-02, Vol.19 (9), p.1123-1131

2000

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NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B

The Journal of biological chemistry, 2003-01, Vol.278 (5), p.2963-2968

2003

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Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

Science (American Association for the Advancement of Science), 1997-12, Vol.278 (5344), p.1812-1815

1997

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Essential Role for Epidermal Growth Factor Receptor in Glutamate Receptor Signaling to NF-κB

Molecular and Cellular Biology, 2008-08, Vol.28 (16), p.5061-5070

2008

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Her2 activates NF-κB and induces invasion through the canonical pathway involving IKKα

Oncogene, 2010-02, Vol.29 (8), p.1238-1248

2010

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IKK-dependent, NF-κB-independent control of autophagic gene expression

Oncogene, 2011-04, Vol.30 (14), p.1727-1732

2011

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Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion

Journal of Immunology, 2007-04, Vol.178 (8), p.4803-4810

2007

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IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway

PloS one, 2010-02, Vol.5 (2), p.e9428

2010

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Abstract 2150: Rapid and efficient evaluation of drug sensitivity in a diverse panel of chordoma xenograft models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2150-2150

2018

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Bioinformatic analysis of selinexor-induced gene expression in patient-derived-chordomas to reveal mechanisms of action leading to tumor growth inhibition

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e23502-e23502

2020

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Expression of the Bcl-3 proto-oncogene suppresses p53 activation

Genes & development, 2006-01, Vol.20 (2), p.225-235

2006

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Abstract 1515: Inhibition of the IKK/NF-κB pathway impairs glioma stem cell function

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1515-1515

2015

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The Kinases MSK1 and MSK2 Are Required for Epidermal Growth Factor-induced, but Not Tumor Necrosis Factor-induced, Histone H3 Ser10 Phosphorylation

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12521-12525

2006

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Abstract 1946: Inhibition of IKK/NF-κB impairs glioma stem cell function

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1946-1946

2014

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Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.LB216-LB216

2021

Volltextzugriff (PDF)

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway

PloS one, 2010-02, Vol.5 (2), p.e9428-e9428

2010

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Abstract 627: Establishment and characterization of a panel of cell-based and patient-derived chordoma tumor models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.627-627

2016

Volltextzugriff (PDF)

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation

Molecular cell, 2012-03, Vol.45 (6), p.719-730

2012

Volltextzugriff (PDF)

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Small-molecule targeting of brachyury transcription factor addiction in chordoma

Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK

The driver landscape of sporadic chordoma

Glycogen Synthase Kinase 3β Functions To Specify Gene-Specific, NF-κB-Dependent Transcription

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

Selective activation of NF-κB subunits in human breast cancer : potential roles for NF-κB2/p52 and for Bcl-3

NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

Essential Role for Epidermal Growth Factor Receptor in Glutamate Receptor Signaling to NF-κB

Her2 activates NF-κB and induces invasion through the canonical pathway involving IKKα

IKK-dependent, NF-κB-independent control of autophagic gene expression

Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway

Abstract 2150: Rapid and efficient evaluation of drug sensitivity in a diverse panel of chordoma xenograft models

Bioinformatic analysis of selinexor-induced gene expression in patient-derived-chordomas to reveal mechanisms of action leading to tumor growth inhibition

Expression of the Bcl-3 proto-oncogene suppresses p53 activation

Abstract 1515: Inhibition of the IKK/NF-κB pathway impairs glioma stem cell function

The Kinases MSK1 and MSK2 Are Required for Epidermal Growth Factor-induced, but Not Tumor Necrosis Factor-induced, Histone H3 Ser10 Phosphorylation

Abstract 1946: Inhibition of IKK/NF-κB impairs glioma stem cell function

Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway

Abstract 627: Establishment and characterization of a panel of cell-based and patient-derived chordoma tumor models

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation

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