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Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

Immunity (Cambridge, Mass.), 2011-03, Vol.34 (3), p.375-384

2011

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Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Scientific reports, 2020-11, Vol.10 (1), p.20085, Article 20085

2020

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Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

Science translational medicine, 2011-03, Vol.3 (73), p.73ra20

2011

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Development of TLR inhibitors for the treatment of autoimmune diseases

Immunological reviews, 2008-06, Vol.223 (1), p.271-283

2008

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RNA recognition by human TLR8 can lead to autoimmune inflammation

The Journal of experimental medicine, 2013-12, Vol.210 (13), p.2903-2919

2013

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

The Journal of experimental medicine, 2005-10, Vol.202 (8), p.1131-1139

2005

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Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

The Journal of experimental medicine, 2010-12, Vol.207 (13), p.2931-2942

2010

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A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma

American journal of respiratory and critical care medicine, 2021-02, Vol.203 (3), p.296-306

2021

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INTERLEUKIN-10 AND THE INTERLEUKIN-10 RECEPTOR

Annual review of immunology, 2001-01, Vol.19 (1), p.683-765

2001

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Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

The Journal of experimental medicine, 2006-08, Vol.203 (8), p.1999-2008

2006

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PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

The Journal of experimental medicine, 2008-02, Vol.205 (2), p.315-322

2008

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Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8⁺ T cells

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (46), p.E7240-E7249

2016

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The Origin of TH2 Responses

Science (American Association for the Advancement of Science), 2010-05, Vol.328 (5982), p.1116-1117

Coffman, Robert L

2010

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Vaccine Adjuvants: Putting Innate Immunity to Work

Immunity (Cambridge, Mass.), 2010-10, Vol.33 (4), p.492-503

2010

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Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells

International immunopharmacology, 2019-01, Vol.66, p.296-308

2019

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A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

The Journal of immunology (1950), 2016-01, Vol.196 (1), p.284-297

2016

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A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice

npj vaccines, 2022-07, Vol.7 (1), p.81-81, Article 81

2022

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New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25

The Journal of immunology (1950), 2002-07, Vol.169 (1), p.443-453

2002

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Origins of the TH1-TH2 model: a personal perspective

Nature immunology, 2006-06, Vol.7 (6), p.539-541

Coffman, Robert L

2006

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Nature medicine, 2007-05, Vol.13 (5), p.552-559

2007

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Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4 + and CD8 + T-cell Interplay

Cancer research (Chicago, Ill.), 2018-09, Vol.78 (17), p.4943-4956

2018

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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

Journal of leukocyte biology, 2003-06, Vol.73 (6), p.781-792

2003

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Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Nature (London), 2021-06, Vol.594 (7862), p.253-258

2021

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OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

Development of TLR inhibitors for the treatment of autoimmune diseases

RNA recognition by human TLR8 can lead to autoimmune inflammation

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma

INTERLEUKIN-10 AND THE INTERLEUKIN-10 RECEPTOR

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8⁺ T cells

The Origin of TH2 Responses

Vaccine Adjuvants: Putting Innate Immunity to Work

Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells

A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice

New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25

Origins of the TH1-TH2 model: a personal perspective

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4 + and CD8 + T-cell Interplay

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

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