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Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

Molecular cancer, 2009-07, Vol.8 (1), p.47-47

2009

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Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

Oncotarget, 2014-05, Vol.5 (9), p.2807-2819

2014

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Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples

Modern pathology, 2012-10, Vol.25 (10), p.1333-1344

2012

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Reovirus Therapy of Tumors with Activated Ras Pathway

Science (American Association for the Advancement of Science), 1998-11, Vol.282 (5392), p.1332-1334

1998

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The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

The EMBO journal, 1998-06, Vol.17 (12), p.3351-3362

1998

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Systemic reovirus therapy of metastatic cancer in immune-competent mice

Cancer research (Chicago, Ill.), 2003-01, Vol.63 (2), p.348-353

2003

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Reovirus oncolysis of human breast cancer

Human gene therapy, 2002-03, Vol.13 (5), p.641-652

2002

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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Science translational medicine, 2018-01, Vol.10 (422)

2018

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Efficacy of function-enhanced, re-activatable, dual-specific CAR T cells pre-loaded with oncolytic virus for immunotherapy of high-grade glioma

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.2062-2062

2023

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BRACELET-1 (PrE0113): Inducing an inflammatory phenotype in metastatic HR+/HER2- breast cancer with the oncolytic reovirus pelareorep in combination with paclitaxel and avelumab

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.1012-1012

2023

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Immune response to reovirus (REO) in phase I study with chemotherapy in patients with KRAS mutant metastatic colorectal cancer (mCRC)

Journal of clinical oncology, 2018-02, Vol.36 (5_suppl), p.217-217

2018

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Treatment with pembrolizumab in combination with the oncolytic virus pelareorep promotes anti-tumor immunity in patients with advanced pancreatic adenocarcinoma

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.4144-4144

2021

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Prediction of response to pelareorep plus pembrolizumab in pancreatic ductal adenocarcinoma (PDAC)

Journal of clinical oncology, 2019-05, Vol.37 (15_suppl), p.e15726-e15726

2019

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Pembrolizumab in combination with the oncolytic virus pelareorep in patients progressing on systemic chemotherapy for advanced pancreatic adenocarcinoma: A phase II study

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e16789-e16789

2020

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Pelareorep to promote the expression of a IFN-gamma-related gene signature that predicts response to checkpoint blockade therapy

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.3089-3089

2018

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Abstract 4420: Serum regulates reovirus-mediated cytopathy in K-Ras activated colorectal cancer and intestinal epithelial cell lines

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.4420-4420

2012

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Hsp90 Phosphorylation Is Linked to Its Chaperoning Function

The Journal of biological chemistry, 2001-08, Vol.276 (35), p.32822-32827

2001

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Oncolytic wild-type reovirus infection in brain tumors following intravenous administration in patients

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.3104-3104

2014

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C-terminal Trimerization, but Not N-terminal Trimerization, of the Reovirus Cell Attachment Protein Is a Posttranslational and Hsp70/ATP-dependent Process

The Journal of biological chemistry, 1996-04, Vol.271 (14), p.8466-8471

1996

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Abstract 1773: The addition of Reolysin, an oncolytic reovirus, to irinotecan shows synergistic anticancer activity in colorectal cancer cell lines

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.1773-1773

2010

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Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein

The Journal of biological chemistry, 2001-08, Vol.276 (35), p.32822-32827

2001

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A multicenter phase I study of intravenous administration of reolysin in combination with irinotecan/fluorouracil/leucovorin (FOLFIRI) in patients (pts) with oxaliplatin-refractory/intolerant KRAS- mutant metastatic colorectal cancer (mCRC)

Journal of clinical oncology, 2013-02, Vol.31 (4_suppl), p.450-450

2013

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Abstract 2594: Reovirus replication in ovarian and peritoneal tumors after intravenous administration

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2594-2594

2010

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1027. A 4-Week Safety Study of Reolysin® Administered by Daily Intravenous Infusion to Cynomolgus Monkeys, with a 4-Week Recovery Period

Molecular therapy, 2004-05, Vol.9 (S1), p.S393-S394

2004

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Active Participation of Hsp90 in the Biogenesis of the Trimeric Reovirus Cell Attachment Protein ς1

The Journal of biological chemistry, 1998-06, Vol.273 (24), p.15227-15233

1998

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Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples

Reovirus Therapy of Tumors with Activated Ras Pathway

The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

Systemic reovirus therapy of metastatic cancer in immune-competent mice

Reovirus oncolysis of human breast cancer

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Efficacy of function-enhanced, re-activatable, dual-specific CAR T cells pre-loaded with oncolytic virus for immunotherapy of high-grade glioma

BRACELET-1 (PrE0113): Inducing an inflammatory phenotype in metastatic HR+/HER2- breast cancer with the oncolytic reovirus pelareorep in combination with paclitaxel and avelumab

Immune response to reovirus (REO) in phase I study with chemotherapy in patients with KRAS mutant metastatic colorectal cancer (mCRC)

Treatment with pembrolizumab in combination with the oncolytic virus pelareorep promotes anti-tumor immunity in patients with advanced pancreatic adenocarcinoma

Prediction of response to pelareorep plus pembrolizumab in pancreatic ductal adenocarcinoma (PDAC)

Pembrolizumab in combination with the oncolytic virus pelareorep in patients progressing on systemic chemotherapy for advanced pancreatic adenocarcinoma: A phase II study

Pelareorep to promote the expression of a IFN-gamma-related gene signature that predicts response to checkpoint blockade therapy

Abstract 4420: Serum regulates reovirus-mediated cytopathy in K-Ras activated colorectal cancer and intestinal epithelial cell lines

Hsp90 Phosphorylation Is Linked to Its Chaperoning Function

Oncolytic wild-type reovirus infection in brain tumors following intravenous administration in patients

C-terminal Trimerization, but Not N-terminal Trimerization, of the Reovirus Cell Attachment Protein Is a Posttranslational and Hsp70/ATP-dependent Process

Abstract 1773: The addition of Reolysin, an oncolytic reovirus, to irinotecan shows synergistic anticancer activity in colorectal cancer cell lines

Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein

A multicenter phase I study of intravenous administration of reolysin in combination with irinotecan/fluorouracil/leucovorin (FOLFIRI) in patients (pts) with oxaliplatin-refractory/intolerant KRAS- mutant metastatic colorectal cancer (mCRC)

Abstract 2594: Reovirus replication in ovarian and peritoneal tumors after intravenous administration

1027. A 4-Week Safety Study of Reolysin® Administered by Daily Intravenous Infusion to Cynomolgus Monkeys, with a 4-Week Recovery Period

Active Participation of Hsp90 in the Biogenesis of the Trimeric Reovirus Cell Attachment Protein ς1

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