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Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection

Cytokine & growth factor reviews, 2014-04, Vol.25 (2), p.91-106

2014

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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Nature communications, 2021-08, Vol.12 (1), p.5137-15, Article 5137

2021

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GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection

PLoS pathogens, 2015-01, Vol.11 (1), p.e1004517-e1004517

2015

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The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease

Nature immunology, 2017-01, Vol.18 (1), p.26

2017

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Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors

Genome medicine, 2018-10, Vol.10 (1), p.81-81, Article 81

2018

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Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Nature communications, 2024-02, Vol.15 (1), p.1094-1094, Article 1094

2024

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Costimulation, a surprising connection for immunotherapy

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6332), p.1373-1374

2017

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The contextual role of TNFR family members in CD8+ T-cell control of viral infections

Immunological reviews, 2013-09, Vol.255 (1), p.125-148

2013

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A real-world retrospective analysis of the management of metastatic castrate-resistant prostate cancer in Ontario, Canada from 2010 – 2018

Urologic oncology, 2023-03, Vol.41 (3), p.146.e13-146.e22

2023

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TNFRs and Control of Chronic LCMV Infection: Implications for Therapy

Trends in immunology, 2015-11, Vol.36 (11), p.697-708

2015

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Real-world treatment patterns and survival outcomes for treated biliary tract cancer patients using administrative databases in Ontario

Journal of gastrointestinal oncology, 2023-08, Vol.14 (4), p.1806-1816

2023

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Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC

The Journal of immunology (1950), 2014-11, Vol.193 (10), p.5033-5043

2014

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Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity

Immunity (Cambridge, Mass.), 2017-11, Vol.47 (5), p.943-958.e9

2017

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Requisite Role for Nck Adaptors in Cardiovascular Development, Endothelial-to-Mesenchymal Transition, and Directed Cell Migration

Molecular and cellular biology, 2015-05, Vol.35 (9), p.1573-1587

2015

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GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology

The Journal of immunology (1950), 2013-05, Vol.190 (9), p.4627-4639

2013

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An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

Journal for immunotherapy of cancer, 2019-03, Vol.7 (1), p.72-12, Article 72

2019

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Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma

Canadian liver journal, 2022-11, Vol.5 (4), p.476-492

2022

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Real-world, population-based study of treatments, survival and healthcare use in advanced urothelial carcinoma of the bladder

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e16538-e16538

2022

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Costs and health care resource utilization (HCRU) for patients with advanced biliary tract (aBTC) cancer using administrative databases in Ontario, 2010 to 2020

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.e16112-e16112

2023

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Role of GITR and its ligand in sustaining T cell responses against influenza infection

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.55-55.27

2016

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Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma

Journal of clinical oncology, 2022-02, Vol.40 (4_suppl), p.400-400

2022

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GITR potentiates anti-viral T cell immunity by limiting regulatory T cells (P1015)

The Journal of immunology (1950), 2013-05, Vol.190 (1_Supplement), p.113-113.8

2013

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GITR/GITRL interaction in the lung provides signal 4 for T cell expansion and TRM formation

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.60-60.1

2018

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TRAF1 in regulation of T cell responses and inflammation

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.193-193.11

2016

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Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection

Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease

Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors

Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Costimulation, a surprising connection for immunotherapy

The contextual role of TNFR family members in CD8+ T-cell control of viral infections

A real-world retrospective analysis of the management of metastatic castrate-resistant prostate cancer in Ontario, Canada from 2010 – 2018

TNFRs and Control of Chronic LCMV Infection: Implications for Therapy

Real-world treatment patterns and survival outcomes for treated biliary tract cancer patients using administrative databases in Ontario

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC

Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity

Requisite Role for Nck Adaptors in Cardiovascular Development, Endothelial-to-Mesenchymal Transition, and Directed Cell Migration

GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma

Real-world, population-based study of treatments, survival and healthcare use in advanced urothelial carcinoma of the bladder

Costs and health care resource utilization (HCRU) for patients with advanced biliary tract (aBTC) cancer using administrative databases in Ontario, 2010 to 2020

Role of GITR and its ligand in sustaining T cell responses against influenza infection

Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma

GITR potentiates anti-viral T cell immunity by limiting regulatory T cells (P1015)

GITR/GITRL interaction in the lung provides signal 4 for T cell expansion and TRM formation

TRAF1 in regulation of T cell responses and inflammation

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