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Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2549-2567

2014

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Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.634

2018

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Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6018-6032

2015

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Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5365-5379

2009

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Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Journal of medicinal chemistry, 2008-06, Vol.51 (12), p.3588-3598

2008

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Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.661-669

2012

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Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

European journal of medicinal chemistry, 2014-09, Vol.84, p.107-117

2014

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Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

European journal of medicinal chemistry, 2015-11, Vol.105, p.120-137

2015

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Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

Bioorganic & medicinal chemistry, 2014-10, Vol.22 (19), p.5298-5307

2014

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Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

International journal of molecular sciences, 2018-09, Vol.19 (9), p.2615

2018

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1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

European journal of medicinal chemistry, 2014-02, Vol.73, p.141-152

2014

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Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation

Basic & clinical pharmacology & toxicology, 2018-01, Vol.122 (1), p.94-103

2018

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Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (23), p.5435-5438

2014

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Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (21), p.5162-5171

2016

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Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

Chemico-biological interactions, 2010-09, Vol.187 (1), p.411-415

2010

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Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (16), p.5156-5167

2015

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Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates

ChemMedChem, 2010-11, Vol.5 (11), p.1855-1870

2010

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Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents

Neuro-degenerative diseases, 2012-01, Vol.10 (1-4), p.96-99

2012

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Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

PloS one, 2013-09, Vol.8 (9), p.e74344

2013

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Anti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice

Natural product research, 2021-05, Vol.35 (10), p.1657-1661

2021

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Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

Frontiers in aging neuroscience, 2018-01, Vol.9, p.435

2018

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Synthesis and Pharmacological Evaluation of Huprine−Tacrine Heterodimers: Subnanomolar Dual Binding Site Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1701-1704

2005

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Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease

Behavioural pharmacology, 2017-04, Vol.28 (2 and 3-Spec Issue), p.124

2017

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Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice

International journal of molecular sciences, 2018-09

2018

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Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis

Molecules (Basel, Switzerland), 2018-03

2018

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Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity

Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates

Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents

Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

Anti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

Synthesis and Pharmacological Evaluation of Huprine−Tacrine Heterodimers: Subnanomolar Dual Binding Site Acetylcholinesterase Inhibitors

Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease

Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice

Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis

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