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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature communications, 2016-08, Vol.7 (1), p.12406-12406, Article 12406

2016

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Development of an integrated rehabilitation pathway for individuals recovering from COVID-19 in the community

Journal of rehabilitation medicine, 2020-08, Vol.52 (8), p.jrm00089-jrm00089

2020

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

EMBO reports, 2011-05, Vol.12 (5), p.463-469

2011

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Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Chemical science (Cambridge), 2017, Vol.8 (11), p.7651-7668

2017

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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

Nature communications, 2022-08, Vol.13 (1), p.4785-4785, Article 4785

2022

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Overcoming Barriers to Remission in Severe Eosinophilic Asthma: Two‐Year Real‐World Data With Benralizumab

Clinical and experimental allergy, 2024-07

2024

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Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del

PloS one, 2024-05, Vol.19 (5), p.e0304555

2024

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Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (26), p.9814-9819

2006

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Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1810-1818

2010

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Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3293-3301

2007

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Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases

Chemistry : a European journal, 2017-09, Vol.23 (52), p.12815-12824

2017

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Anti-IL-5 biologics and rheumatoid arthritis: a single-centre 500 patient year exposure analysis

Rheumatic & musculoskeletal diseases open, 2023-12, Vol.9 (4), p.e003583

2023

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Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

Structure (London), 2002, Vol.10 (1), p.93-103

2002

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Structural studies on human 2-oxoglutarate dependent oxygenases

Current opinion in structural biology, 2010-12, Vol.20 (6), p.659-672

2010

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Ward based inhaler technique service reduces exacerbations of asthma and COPD

Respiratory medicine, 2021-10, Vol.187, p.106583-106583, Article 106583

2021

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Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Organic & biomolecular chemistry, 2011-09, Vol.9 (18), p.6219-6225

2011

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Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins

Journal of inorganic biochemistry, 2006-04, Vol.100 (4), p.644-669

2006

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Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains

Chembiochem : a European journal of chemical biology, 2023-02, Vol.24 (4), p.e202200576-n/a

2023

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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

Molecular bioSystems, 2005-10, Vol.1 (4), p.321-324

2005

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Physical activity promotion interventions in chronic airways disease: a systematic review and meta-analysis

European respiratory review, 2023-03, Vol.32 (167), p.220109

2023

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Crystal Structure of Carbapenem Synthase (CarC)

The Journal of biological chemistry, 2003-06, Vol.278 (23), p.20843-20850

2003

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Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Nature (London), 2014-06, Vol.510 (7505), p.422-426

2014

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The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

Nature (London), 1999-10, Vol.401 (6754), p.721-724

1999

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Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Nature (London), 1995-06, Vol.375 (6533), p.700-704

1995

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Breathlessness in palliative care: a practical guide

British journal of hospital medicine (London, England : 2005), 2019-02, Vol.80 (2), p.72-77

2019

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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Development of an integrated rehabilitation pathway for individuals recovering from COVID-19 in the community

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

Overcoming Barriers to Remission in Severe Eosinophilic Asthma: Two‐Year Real‐World Data With Benralizumab

Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del

Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases

Anti-IL-5 biologics and rheumatoid arthritis: a single-centre 500 patient year exposure analysis

Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

Structural studies on human 2-oxoglutarate dependent oxygenases

Ward based inhaler technique service reduces exacerbations of asthma and COPD

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins

Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

Physical activity promotion interventions in chronic airways disease: a systematic review and meta-analysis

Crystal Structure of Carbapenem Synthase (CarC)

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Breathlessness in palliative care: a practical guide

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