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Interaction of Common Azole Antifungals with P Glycoprotein

Antimicrobial Agents and Chemotherapy, 2002-01, Vol.46 (1), p.160-165

2002

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A high-throughput LC–MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography

Journal of pharmaceutical and biomedical analysis, 2009-08, Vol.50 (1), p.46-52

2009

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Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography–tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-07, Vol.792 (2), p.229-240

2003

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Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein

Drug metabolism and disposition, 2001-08, Vol.29 (8), p.1080

2001

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Quantitative Distinctions of Active Site Molecular Recognition by P-Glycoprotein and Cytochrome P450 3A4

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1596-1603

2001

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Validation and application of a liquid chromatography–tandem mass spectrometric method for the determination of SCH 211803 in rat and monkey plasma using automated 96-well protein precipitation

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-01, Vol.799 (2), p.271-280

2004

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A Dose-Ranging Study of Pegylated Interferon Alfa-2b and Ribavirin in Chronic Hepatitis C

Hepatology (Baltimore, Md.), 2000-09, Vol.32 (3), p.647-653

2000

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Evaluation of a Four-Channel Multiplexed Electrospray Triple Quadrupole Mass Spectrometer for the Simultaneous Validation of LC/MS/MS Methods in Four Different Preclinical Matrixes

Analytical chemistry (Washington), 2001-04, Vol.73 (8), p.1740-1747

2001

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Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2007-09, Vol.21 (18), p.3145-3155

2007

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Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC–MS/MS separations

Journal of pharmaceutical and biomedical analysis, 2011-01, Vol.54 (1), p.179-185

2011

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Determination of a novel thrombin receptor antagonist (SCH 530348) in human plasma: Evaluation of Ultra Performance Liquid Chromatography™–tandem mass spectrometry for routine bioanalytical analysis

Journal of pharmaceutical and biomedical analysis, 2011-05, Vol.55 (2), p.349-359

2011

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In vitro flow cytometry method to quantitatively assess inhibitors of P-glycoprotein

Drug metabolism and disposition, 2000-05, Vol.28 (5), p.522

2000

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Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis

Bioanalysis, 2011-04, Vol.3 (7), p.735-743

2011

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Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers

Journal of clinical pharmacology, 2000-11, Vol.40 (11), p.1227-1236

2000

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Stereoselective quantitation of a serine protease inhibitor using LC-MS/MS at elevated column temperature

Journal of separation science, 2008-02, Vol.31 (2), p.242-254

2008

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Conference Report: 12th Annual University of Wisconsin Land O’Lakes Bioanalytical Conference

Bioanalysis, 2011-10, Vol.3 (19), p.2171-2175

2011

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In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

Drug metabolism and disposition, 2001-09, Vol.29 (9), p.1173

2001

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Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: Evidence for contingent unequal binding sites

Pharmaceutical research, 2003-04, Vol.20 (4), p.537-544

2003

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The single dose pharmacokinetics of ribavirin in subjects with chronic liver disease

British journal of clinical pharmacology, 2000-05, Vol.49 (5), p.417-421

2000

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Conference Report: Summary of The Eleventh Annual University of Wisconsin Land O’Lakes Bioanalytical Conference

Bioanalysis, 2010-10, Vol.2 (10), p.1677-1681

2010

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Summary of the Eleventh Annual University of Wisconsin Land O'Lakes Bioanalytical Conference

Bioanalysis, 2010-10, Vol.2 (10), p.1677

2010

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Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.863

2001

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HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

Pharmaceutical research, 2001-06, Vol.18 (6), p.800-806

2001

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Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence

Biochimica et biophysica acta, 2000-08, Vol.1481 (1), p.63-74

2000

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Preclinical Drug Metabolism Programs for Food-Producing Animals

Toxicologic pathology, 1995-03, Vol.23 (2), p.209-216

Clement, Robert P.

1995

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Interaction of Common Azole Antifungals with P Glycoprotein

A high-throughput LC–MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography

Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography–tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma

Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein

Quantitative Distinctions of Active Site Molecular Recognition by P-Glycoprotein and Cytochrome P450 3A4

Validation and application of a liquid chromatography–tandem mass spectrometric method for the determination of SCH 211803 in rat and monkey plasma using automated 96-well protein precipitation

A Dose-Ranging Study of Pegylated Interferon Alfa-2b and Ribavirin in Chronic Hepatitis C

Evaluation of a Four-Channel Multiplexed Electrospray Triple Quadrupole Mass Spectrometer for the Simultaneous Validation of LC/MS/MS Methods in Four Different Preclinical Matrixes

Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry

Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC–MS/MS separations

Determination of a novel thrombin receptor antagonist (SCH 530348) in human plasma: Evaluation of Ultra Performance Liquid Chromatography™–tandem mass spectrometry for routine bioanalytical analysis

In vitro flow cytometry method to quantitatively assess inhibitors of P-glycoprotein

Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis

Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers

Stereoselective quantitation of a serine protease inhibitor using LC-MS/MS at elevated column temperature

Conference Report: 12th Annual University of Wisconsin Land O’Lakes Bioanalytical Conference

In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: Evidence for contingent unequal binding sites

The single dose pharmacokinetics of ribavirin in subjects with chronic liver disease

Conference Report: Summary of The Eleventh Annual University of Wisconsin Land O’Lakes Bioanalytical Conference

Summary of the Eleventh Annual University of Wisconsin Land O'Lakes Bioanalytical Conference

Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence

Preclinical Drug Metabolism Programs for Food-Producing Animals

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