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Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

Nature communications, 2020-02, Vol.11 (1), p.694-13, Article 694

2020

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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Nature biotechnology, 2009-12, Vol.27 (12), p.1186-1190

2009

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Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer's disease mouse model

Alzheimer's research & therapy, 2024-05, Vol.16 (1), p.101-14, Article 101

2024

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Vascular Endothelial Growth Factor Stimulates Bone Repair by Promoting Angiogenesis and Bone Turnover

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (15), p.9656-9661

2002

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A Randomized Safety and Efficacy Study of Somavaratan (VRS-317), a Long-Acting rhGH, in Pediatric Growth Hormone Deficiency

The journal of clinical endocrinology and metabolism, 2016-03, Vol.101 (3), p.1091-1097

2016

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Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose

PloS one, 2010-04, Vol.5 (4), p.e10175

2010

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A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Journal of pharmaceutical sciences, 2001-03, Vol.90 (3), p.310-321

2001

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Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer

Clinical cancer research, 2007-04, Vol.13 (7), p.2216-2225

2007

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A Transient Expansion of the Native State Precedes Aggregation of Recombinant Human interferon-γ

Proceedings of the National Academy of Sciences - PNAS, 1998-11, Vol.95 (24), p.14142-14146

1998

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New advances in microsphere-based single-dose vaccines

Advanced drug delivery reviews, 1997-10, Vol.28 (1), p.97-119

1997

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A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life

Journal of pharmaceutical sciences, 2012-08, Vol.101 (8), p.2744-2754

2012

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Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

Bioengineering & translational medicine, 2018-05, Vol.3 (2), p.87-101

2018

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A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults

The journal of clinical endocrinology and metabolism, 2013-06, Vol.98 (6), p.2595-2603

2013

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Emerging protein delivery methods

Current Opinion in Biotechnology, 2001-04, Vol.12 (2), p.212-219

2001

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Application of high hydrostatic pressure to dissociate aggregates and refold proteins

Current pharmaceutical biotechnology, 2009-06, Vol.10 (4), p.447-455

2009

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Development of poly-( d, l-lactide–coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis

Journal of controlled release, 2001-05, Vol.72 (1), p.13-24

2001

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Effect of Glycine on pH Changes and Protein Stability During Freeze–Thawing in Phosphate Buffer Systems

Journal of pharmaceutical sciences, 2002-09, Vol.91 (9), p.1969-1979

2002

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A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Journal of pharmaceutical sciences, 2001-03, Vol.90 (3), p.310-321

2001

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Single-administration vaccines: controlled-release technology to mimic repeated immunizations

Trends in Biotechnology, 1999, Vol.17 (1), p.25-29

Cleland, Jeffrey L

1999

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Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect

Journal of controlled release, 1997-12, Vol.49 (2), p.193-205

1997

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Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

Journal of pharmaceutical sciences, 1998-12, Vol.87 (12), p.1554-1559

1998

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Effects of annealing lyophilized and spray‐lyophilized formulations of recombinant human interferon‐γ

Journal of pharmaceutical sciences, 2003-04, Vol.92 (4), p.715-729

2003

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Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes

Journal of controlled release, 2000-07, Vol.67 (2), p.281-292

2000

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Refolding and aggregation of bovine carbonic anhydrase B: quasi-elastic light scattering analysis

Biochemistry (Easton), 1990-12, Vol.29 (50), p.11072-11078

1990

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Surface adsorption of recombinant human interferon‐γ in lyophilized and spray‐lyophilized formulations

Journal of pharmaceutical sciences, 2002-06, Vol.91 (6), p.1474-1487

2002

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Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer's disease mouse model

Vascular Endothelial Growth Factor Stimulates Bone Repair by Promoting Angiogenesis and Bone Turnover

A Randomized Safety and Efficacy Study of Somavaratan (VRS-317), a Long-Acting rhGH, in Pediatric Growth Hormone Deficiency

Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer

A Transient Expansion of the Native State Precedes Aggregation of Recombinant Human interferon-γ

New advances in microsphere-based single-dose vaccines

A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life

Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults

Emerging protein delivery methods

Application of high hydrostatic pressure to dissociate aggregates and refold proteins

Development of poly-( d, l-lactide–coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis

Effect of Glycine on pH Changes and Protein Stability During Freeze–Thawing in Phosphate Buffer Systems

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Single-administration vaccines: controlled-release technology to mimic repeated immunizations

Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

Effects of annealing lyophilized and spray‐lyophilized formulations of recombinant human interferon‐γ

Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes

Refolding and aggregation of bovine carbonic anhydrase B: quasi-elastic light scattering analysis

Surface adsorption of recombinant human interferon‐γ in lyophilized and spray‐lyophilized formulations

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