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Rescue of conformational dynamics in enzyme catalysis by directed evolution

Nature communications, 2018-04, Vol.9 (1), p.1314-11, Article 1314

2018

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Role of Structural Plasticity in Signal Transduction by the Cryptochrome Blue-Light Photoreceptor

Biochemistry (Easton), 2005-03, Vol.44 (10), p.3795-3805

2005

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Dynamic Coupling and Allosteric Behavior in a Nonallosteric Protein

Biochemistry (Easton), 2006-06, Vol.45 (25), p.7693-7699

2006

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Hidden alternative structures of proline isomerase essential for catalysis

Nature (London), 2009-12, Vol.462 (7273), p.669-673

2009

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Cooperative dynamics across distinct structural elements regulate PTP1B activity

The Journal of biological chemistry, 2020-10, Vol.295 (40), p.13829-13837

2020

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Long-Range Dynamic Effects of Point Mutations Propagate through Side Chains in the Serine Protease Inhibitor Eglin c

Biochemistry (Easton), 2004-10, Vol.43 (39), p.12448-12458

2004

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Dynamic activation and regulation of the mitogen-activated protein kinase p38

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.4655-4660

2018

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Antiparallel EmrE exports drugs by exchanging between asymmetric structures

Nature (London), 2012-01, Vol.481 (7379), p.45-50

2012

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NMR Based SARS-CoV‑2 Antibody Screening

Journal of the American Chemical Society, 2021-06, Vol.143 (21), p.7930-7934

2021

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Conserved conformational dynamics determine enzyme activity

Science advances, 2022-08, Vol.8 (31), p.eabo5546-eabo5546

2022

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Evidence Against the “Y–T Coupling” Mechanism of Activation in the Response Regulator NtrC

Journal of molecular biology, 2014-04, Vol.426 (7), p.1554-1567

2014

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Physachenolide C is a Potent, Selective BET Inhibitor

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.913-933

2023

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Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization

Biochemistry (Easton), 2019-10, Vol.58 (41), p.4183-4194

2019

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Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein

Cell, 2009-12, Vol.139 (6), p.1109-1118

2009

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Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR

Journal of molecular biology, 2010-11, Vol.403 (5), p.723-738

2010

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Ligand Binding Reduces Conformational Flexibility in the Active Site of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from Pseudomonasaeruginosa

Journal of molecular biology, 2013-06, Vol.425 (12), p.2219-2231

2013

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Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining

Biochemistry (Easton), 2007-10, Vol.46 (43), p.12100

2007

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Increased Rigidity of Eglin c at Acidic pH: Evidence from NMR Spin Relaxation and MD Simulations

Biochemistry (Easton), 2003-12, Vol.42 (47), p.13856-13868

2003

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Role of Protein Dynamics in the Function of p38 Kinase and Protein Tyrosine Phosphatase 1B

Biophysical journal, 2020-02, Vol.118 (3), p.519a-519a

2020

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Ligand Binding Reduces Conformational Flexibility in the Active Site of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from Pseudomonas aeruginosa

Journal of molecular biology, 2013-06, Vol.425 (12), p.2219-2231

2013

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Activation Mechanism of a Signaling Protein at Atomic Resolution

Biophysical journal, 2015-01, Vol.108 (2), p.376a-376a

2015

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Cyclophilin Dynamics and Catalysis are Mechanistically Linked

Biophysical journal, 2009-02, Vol.96 (3), p.555a-555a

2009

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Hidden alternate structures of proline isomerase essential for catalysis

Nature (London), 2009-12, Vol.462 (7273), p.669-673

2009

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Dissecting the microscopic steps of the cyclophilin a enzymatic cycle on the biological substrate HIV-capsid by NMR

Journal of molecular biology, 2010, Vol.403 (5), p.723

2010

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Solution Structure of Polymerase μ's BRCT Domain Reveals an Element Essential for Its Role in Nonhomologous End Joining

Biochemistry (Easton), 2007-10, Vol.46 (43), p.12100-12110

2007

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Rescue of conformational dynamics in enzyme catalysis by directed evolution

Role of Structural Plasticity in Signal Transduction by the Cryptochrome Blue-Light Photoreceptor

Dynamic Coupling and Allosteric Behavior in a Nonallosteric Protein

Hidden alternative structures of proline isomerase essential for catalysis

Cooperative dynamics across distinct structural elements regulate PTP1B activity

Long-Range Dynamic Effects of Point Mutations Propagate through Side Chains in the Serine Protease Inhibitor Eglin c

Dynamic activation and regulation of the mitogen-activated protein kinase p38

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

NMR Based SARS-CoV‑2 Antibody Screening

Conserved conformational dynamics determine enzyme activity

Evidence Against the “Y–T Coupling” Mechanism of Activation in the Response Regulator NtrC

Physachenolide C is a Potent, Selective BET Inhibitor

Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization

Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein

Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR

Ligand Binding Reduces Conformational Flexibility in the Active Site of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from Pseudomonasaeruginosa

Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining

Increased Rigidity of Eglin c at Acidic pH: Evidence from NMR Spin Relaxation and MD Simulations

Role of Protein Dynamics in the Function of p38 Kinase and Protein Tyrosine Phosphatase 1B

Ligand Binding Reduces Conformational Flexibility in the Active Site of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from Pseudomonas aeruginosa

Activation Mechanism of a Signaling Protein at Atomic Resolution

Cyclophilin Dynamics and Catalysis are Mechanistically Linked

Hidden alternate structures of proline isomerase essential for catalysis

Dissecting the microscopic steps of the cyclophilin a enzymatic cycle on the biological substrate HIV-capsid by NMR

Solution Structure of Polymerase μ's BRCT Domain Reveals an Element Essential for Its Role in Nonhomologous End Joining

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