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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.280-284

2006

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Intra- or Intercomplex Binding to the γ-Secretase Enzyme: A MODEL TO DIFFERENTIATE INHIBITOR CLASSES

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31279-31289

2006

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Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

Journal of medicinal chemistry, 2009-06, Vol.52 (11), p.3441-3444

2009

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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12523-12535

2005

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A new series of potent benzodiazepine γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (2), p.179-183

2003

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Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay

Journal of neuroscience methods, 2000-10, Vol.102 (1), p.61-68

2000

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High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4143-4145

2003

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Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Journal of neurochemistry, 2004-09, Vol.90 (6), p.1312-1320

2004

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Intra- or Intercomplex Binding to the γ-Secretase Enzyme

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31279-31289

2006

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Intra- or Intercomplex Binding to the Î³-Secretase Enzyme

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31279

2006

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Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target Î³-Secretase at a Novel Site

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419

2004

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Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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S2-03-02: Mechanistic differences in targeting γ-secretase with inhibitors

Alzheimer's & dementia, 2006-07, Vol.2 (3), p.S26-S27

2006

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Functional Overexpression of Î³-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12523

2005

Volltextzugriff (PDF)

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2 S ,3 R )-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy- N -((3 S )-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1 H -benzo[ e ][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

Volltextzugriff (PDF)

Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors: Preparation of (2S, 3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-o xo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement

Journal of medicinal chemistry, 2003, Vol.46 (12), p.2275-2278

2003

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High Affinity, Bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase Inhibitors

ChemInform, 2004-03, Vol.35 (10), p.no-no

2004

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A New Series of Potent Benzodiazepine γ-Secretase Inhibitors

ChemInform, 2003-05, Vol.34 (18), p.no-no

2003

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Potential for Cure by Stage across the Cancer Spectrum in the United States

Cancer epidemiology, biomarkers & prevention, 2024-02, Vol.33 (2), p.206

2024

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Relationship Between Genetic Risk and Age of Diagnosis in Systemic Lupus Erythematosus

Journal of rheumatology, 2021-06, Vol.48 (6), p.852

2021

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Intra- or Intercomplex Binding to the γ-Secretase Enzyme: A MODEL TO DIFFERENTIATE INHIBITOR CLASSES

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

A new series of potent benzodiazepine γ-secretase inhibitors

Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay

High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

Intra- or Intercomplex Binding to the γ-Secretase Enzyme

Intra- or Intercomplex Binding to the Î³-Secretase Enzyme

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target Î³-Secretase at a Novel Site

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

S2-03-02: Mechanistic differences in targeting γ-secretase with inhibitors

Functional Overexpression of Î³-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors: Preparation of (2S, 3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-o xo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement

High Affinity, Bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase Inhibitors

A New Series of Potent Benzodiazepine γ-Secretase Inhibitors

Potential for Cure by Stage across the Cancer Spectrum in the United States

Relationship Between Genetic Risk and Age of Diagnosis in Systemic Lupus Erythematosus

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