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Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease

Current pharmaceutical design, 2005-10, Vol.11 (26), p.3353

2005

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Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.973-980

1998

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HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use

Proceedings of the National Academy of Sciences - PNAS, 2002-01, Vol.99 (1), p.395-400

2002

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Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

Journal of Virology, 2003-05, Vol.77 (9), p.5201-5208

2003

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SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo

Proceedings of the National Academy of Sciences - PNAS, 2001-10, Vol.98 (22), p.12718-12723

2001

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Discovery of 4-[(Z)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3339-3342

2001

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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2294-2310

2006

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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2274-2277

2005

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2-Azetidinones as Inhibitors of Cholesterol Absorption

Journal of medicinal chemistry, 1994-06, Vol.37 (12), p.1733-1736

1994

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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.3143-3160

2002

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2-Azetidinone Cholesterol Absorption Inhibitors: Structure−Activity Relationships on the Heterocyclic Nucleus

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3684-3693

1996

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The Discovery of Ezetimibe: A View from Outside the Receptor

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.1-9

Clader, John W

2004

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Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity

Journal of medicinal chemistry, 1998-02, Vol.41 (5), p.752-759

1998

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Interaction of small molecule inhibitors of HIV-1 entry with CCR5

Virology (New York, N.Y.), 2006-05, Vol.349 (1), p.41-54

2006

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Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4875-4877

1995

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Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

Farmaco (Società chimica italiana : 1989), 2001-04, Vol.56 (4), p.247-250

2001

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Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

European journal of pharmacology, 2006-03, Vol.535 (1), p.182-191

2006

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Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1600-1607

1995

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Synthesis and receptor affinities of some conformationally restricted analogs of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol

Journal of medicinal chemistry, 1989-08, Vol.32 (8), p.1913-1921

1989

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Ezetimibe and other azetidinone cholesterol absorption inhibitors

Current topics in medicinal chemistry, 2005-01, Vol.5 (3), p.243

Clader, John W

2005

Volltextzugriff (PDF)

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2247-2250

2000

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Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors

Tetrahedron letters, 1996-06, Vol.37 (24), p.4095-4098

1996

Volltextzugriff (PDF)

Supracondylar humeral osteotomy for traumatic childhood cubitus varus deformity

Clinical orthopaedics and related research, 1984-09, Vol.188 (188), p.34-39

1984

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Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4746-4749

2005

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A comparison of different methods used to diagnose pseudarthrosis following posterior spinal fusion for scoliosis

Journal of bone and joint surgery. American volume, 1985-10, Vol.67 (8), p.1153

1985

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Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease

Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use

Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo

Discovery of 4-[(Z)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection

Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas

Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics

2-Azetidinones as Inhibitors of Cholesterol Absorption

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

2-Azetidinone Cholesterol Absorption Inhibitors: Structure−Activity Relationships on the Heterocyclic Nucleus

The Discovery of Ezetimibe: A View from Outside the Receptor

Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity

Interaction of small molecule inhibitors of HIV-1 entry with CCR5

Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Synthesis and receptor affinities of some conformationally restricted analogs of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol

Ezetimibe and other azetidinone cholesterol absorption inhibitors

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors

Supracondylar humeral osteotomy for traumatic childhood cubitus varus deformity

Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

A comparison of different methods used to diagnose pseudarthrosis following posterior spinal fusion for scoliosis

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