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Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α1d Adrenergic Receptor

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1900-1918

2004

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Selective γ‐hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ‐hydroxybutyric acid

Journal of neurochemistry, 2003-11, Vol.87 (3), p.722-732

2003

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Synthesis and Cytotoxic Activities of Pyrrole[2,3-d]pyridazin-4-one Derivatives

Chemical and Pharmaceutical Bulletin, 2002, Vol.50(6), pp.754-759

2002

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Synthesis, Activity, and Molecular Modeling of a New Series of Tricyclic Pyridazinones as Selective Aldose Reductase Inhibitors

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4396-4405

1996

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New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications

Expert opinion on therapeutic patents, 1997-08, Vol.7 (8), p.843-858

1997

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Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches

Medicinal research reviews, 1999-01, Vol.19 (1), p.3-23

1999

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Role of GABAB receptors in the sedative/hypnotic effect of γ-hydroxybutyric acid

European journal of pharmacology, 2001-10, Vol.428 (3), p.315-321

2001

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Synthesis, Modelling, and Antimitotic Properties of Tricyclic Systems Characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole Moiety

ChemMedChem, 2009-06, Vol.4 (6), p.998-1009

2009

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Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid

European journal of pharmacology, 2002-04, Vol.441 (3), p.157-163

2002

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Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

Bioorganic & medicinal chemistry, 2006-02, Vol.14 (3), p.676-691

2006

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Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid

European journal of pharmacology, 2002-04, Vol.441 (3), p.157-163

2002

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6-Chloropyridazin-3-yl Derivatives Active as Nicotinic Agents: Synthesis, Binding, and Modeling Studies

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.4011-4017

2002

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Conformationally constrained congeners of 6-aryl-5-methyl-4,5-dihydro-3(2H)-pyridazinones active on the cardiovascular system: conformational studies by molecular mechanics calculations and proton NMR spectroscopy

Journal of medicinal chemistry, 1990-06, Vol.33 (6), p.1591-1594

1990

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Stereoselectivity of NCS-382 binding to γ-hydroxybutyrate receptor in the rat brain

European journal of pharmacology, 2002-06, Vol.446 (1), p.1-5

2002

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Phenylpiperazinylalkylamino Substituted Pyridazinones as Potent α1 Adrenoceptor Antagonists

Journal of medicinal chemistry, 2001-07, Vol.44 (15), p.2403-2410

2001

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Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling

Journal of medicinal chemistry, 1998-02, Vol.41 (5), p.674-681

1998

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Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity and opioid antinociception

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.4015-4026

2003

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The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics

European journal of medicinal chemistry, 2000-03, Vol.35 (3), p.275-282

2000

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Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1900

2004

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Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α 1d Adrenergic Receptor

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1900-1918

2004

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N-3(9)-Arylpropenyl- N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as μ-Opioid receptor agonists. Effects on μ-Affinity of arylalkenyl chain modifications

Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.1929-1937

2002

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Central effects of 1,4-butanediol are mediated by GABA B receptors via its conversion into γ-hydroxybutyric acid

European journal of pharmacology, 2002, Vol.441 (3), p.157-163

2002

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Novel Adrenoceptor Antagonists with a Tricyclic Pyrrolodipyridazine Skeleton

Journal of medicinal chemistry, 1999-01, Vol.42 (1), p.173-177

1999

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Synthesis, Molecular Modeling, and Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5]decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes

Journal of medicinal chemistry, 2000-06, Vol.43 (11), p.2115-2123

2000

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Hydroxymethylation of 3-Aroylpropanoic Acids; An Improved Synthesis of 4-Aroyl-2(3H)-dihydrofuranones and an Easy Approach to 3-Aroyl-3-butenoic Acids

Synthesis (Stuttgart), 1980-01, Vol.1980 (10), p.825-828

1980

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Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α1d Adrenergic Receptor

Selective γ‐hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ‐hydroxybutyric acid

Synthesis and Cytotoxic Activities of Pyrrole[2,3-d]pyridazin-4-one Derivatives

Synthesis, Activity, and Molecular Modeling of a New Series of Tricyclic Pyridazinones as Selective Aldose Reductase Inhibitors

New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications

Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches

Role of GABAB receptors in the sedative/hypnotic effect of γ-hydroxybutyric acid

Synthesis, Modelling, and Antimitotic Properties of Tricyclic Systems Characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole Moiety

Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid

6-Chloropyridazin-3-yl Derivatives Active as Nicotinic Agents: Synthesis, Binding, and Modeling Studies

Conformationally constrained congeners of 6-aryl-5-methyl-4,5-dihydro-3(2H)-pyridazinones active on the cardiovascular system: conformational studies by molecular mechanics calculations and proton NMR spectroscopy

Stereoselectivity of NCS-382 binding to γ-hydroxybutyrate receptor in the rat brain

Phenylpiperazinylalkylamino Substituted Pyridazinones as Potent α1 Adrenoceptor Antagonists

Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling

Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity and opioid antinociception

The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics

Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor

Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α 1d Adrenergic Receptor

N-3(9)-Arylpropenyl- N-9(3)-propionyl-3,9-diazabicyclo[3.3.1]nonanes as μ-Opioid receptor agonists. Effects on μ-Affinity of arylalkenyl chain modifications

Central effects of 1,4-butanediol are mediated by GABA B receptors via its conversion into γ-hydroxybutyric acid

Novel Adrenoceptor Antagonists with a Tricyclic Pyrrolodipyridazine Skeleton

Synthesis, Molecular Modeling, and Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5]decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes

Hydroxymethylation of 3-Aroylpropanoic Acids; An Improved Synthesis of 4-Aroyl-2(3H)-dihydrofuranones and an Easy Approach to 3-Aroyl-3-butenoic Acids

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