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QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators

Journal of molecular graphics & modelling, 2014-09, Vol.53, p.82-91

2014

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Pharmacological Advances in the Treatment of Age-related Macular Degeneration

Current medicinal chemistry, 2020-01, Vol.27 (4), p.583-598

2020

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Discovery and Kinetic Profiling of 7‑Aryl-1,2,4-triazolo[4,3‑a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6704-6720

2017

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Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.223-233

2019

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Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

The Journal of pharmacology and experimental therapeutics, 2013-09, Vol.346 (3), p.514-527

2013

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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8685-8699

2012

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mGluR2 positive allosteric modulators: a patent review (2009 - present)

Expert opinion on therapeutic patents, 2013-05, Vol.23 (5), p.629-647

2013

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Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2688-2701

2012

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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6495-6512

2014

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Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

Pharmaceuticals (Basel, Switzerland), 2024-01, Vol.17 (2), p.157

2024

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The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

Pharmaceutics, 2024-01, Vol.16 (1), p.105

2024

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Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin Derivatives as Potential Anxiolytic Agents

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(2), pp.262-265

2004

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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.971-976

2011

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Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration

Investigative ophthalmology & visual science, 2023-10, Vol.64 (13), p.34-34

2023

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Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813

Pharmacology research & perspectives, 2015-03, Vol.3 (2), p.e00097-n/a

2015

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mGluR2 positive allosteric modulators: an updated patent review (2013-2018)

Expert opinion on therapeutic patents, 2019-07, Vol.29 (7), p.497-507

2019

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Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor

Pharmacology research & perspectives, 2015-02, Vol.3 (1), p.e00096-n/a

2015

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Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8770-8789

2012

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Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

British journal of pharmacology, 2016-02, Vol.173 (3), p.588-600

2016

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Snoezelen and Dementia: a Case Study

Social Pathology and Prevention, 2022-01, Vol.7 (1), p.61-75

2022

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Spiro-oxindole Piperidines and 3‑(Azetidin-3-yl)‑1H‑benzimidazol-2-ones as mGlu2 Receptor PAMs

ACS medicinal chemistry letters, 2020-03, Vol.11 (3), p.303-308

2020

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Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor

ACS chemical neuroscience, 2019-03, Vol.10 (3), p.1043-1054

2019

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Scaffold hopping from pyridones to imidazo[1,2- a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.175-179

2010

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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2388-2405

2012

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QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators

Pharmacological Advances in the Treatment of Age-related Macular Degeneration

Discovery and Kinetic Profiling of 7‑Aryl-1,2,4-triazolo[4,3‑a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

mGluR2 positive allosteric modulators: a patent review (2009 - present)

Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin Derivatives as Potential Anxiolytic Agents

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration

Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813

mGluR2 positive allosteric modulators: an updated patent review (2013-2018)

Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor

Discovery of 3‑Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3‑a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

Snoezelen and Dementia: a Case Study

Spiro-oxindole Piperidines and 3‑(Azetidin-3-yl)‑1H‑benzimidazol-2-ones as mGlu2 Receptor PAMs

Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor

Scaffold hopping from pyridones to imidazo[1,2- a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

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