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Clinical development of the oral gonadotropin-releasing hormone antagonist elagolix

F&S Reports (Online), 2023-06, Vol.4 (2), p.65-72

Chwalisz, Kristof

2023

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Clinical development of the GnRH agonist leuprolide acetate depot

F&S Reports (Online), 2023-06, Vol.4 (2), p.33-39

Chwalisz, Kristof

2023

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Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density

Reproductive sciences (Thousand Oaks, Calif.), 2014-11, Vol.21 (11), p.1341-1351

2014

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Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study

Fertility and sterility, 2017-07, Vol.108 (1), p.152-160.e4

2017

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Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation

Fertility and sterility, 1996-03, Vol.65 (3), p.477-483

1996

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A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata

Fertility and sterility, 2007-06, Vol.87 (6), p.1399-1412

2007

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Current and Emerging Medical Treatments for Uterine Fibroids

Seminars in reproductive medicine, 2017-11, Vol.35 (6), p.510-522

2017

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Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by Elagolix in Healthy Premenopausal Women

The journal of clinical endocrinology and metabolism, 2017-05, Vol.102 (5), p.1683-1691

2017

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Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

The New England journal of medicine, 2017-07, Vol.377 (1), p.28-40

2017

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Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive biology and endocrinology, 2006-10, Vol.4 Suppl 1 (S1), p.S8-S8, Article S8

2006

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Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.5010-5016

2000

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Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Endocrine reviews, 2005-05, Vol.26 (3), p.423-438

2005

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Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies

Obstetrics and gynecology (New York. 1953), 2018-07, Vol.132 (1), p.147-160

2018

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Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire

Current medical research and opinion, 2017-02, Vol.33 (2), p.193-200

2017

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Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial

Obstetrics and gynecology (New York. 1953), 2018-11, Vol.132 (5), p.1252-1264

2018

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Pre-eclampsia-like conditions produced by nitric oxide inhibition: effects of L-arginine, D-arginine and steroid hormones

Human reproduction (Oxford), 1995-10, Vol.10 (10), p.2723-2730

1995

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Long-term Effect of Elagolix on Bone Mineral Density in Women with Endometriosis-Associated Pain [38G]

Obstetrics and gynecology (New York. 1953), 2018-05, Vol.131 (1), p.85-86S

2018

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Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Reproductive sciences (Thousand Oaks, Calif.), 2014-03, Vol.21 (3), p.363-371

2014

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Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women

The journal of clinical endocrinology and metabolism, 2020-03, Vol.105 (3), p.821-832

2020

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Modulation of the Action of Chorionic Gonadotropin in the Baboon (Papio anubis) Uterus by a Progesterone Receptor Antagonist (ZK 137.316)

Biology of reproduction, 2000-09, Vol.63 (3), p.820-825

2000

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The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis

Reproductive sciences (Thousand Oaks, Calif.), 2012-06, Vol.19 (6), p.563-571

2012

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Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain

Pain management, 2019-09, Vol.9 (5), p.497-515

2019

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Validation of the Menstrual Pictogram in Women With Leiomyomata Associated With Heavy Menstrual Bleeding

Reproductive sciences (Thousand Oaks, Calif.), 2013-06, Vol.20 (6), p.680-687

2013

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Long-Term Safety and Efficacy of Elagolix Treatment in Women With Endometriosis-Associated Pain [11OP]

Obstetrics and gynecology (New York. 1953), 2018-05, Vol.131 (1), p.4-4S

2018

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Development and Validation of the Endometriosis Daily Pain Impact Diary Items to Assess Dysmenorrhea and Nonmenstrual Pelvic Pain

Reproductive sciences (Thousand Oaks, Calif.), 2018-11, Vol.25 (11), p.1567-1576

2018

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Clinical development of the oral gonadotropin-releasing hormone antagonist elagolix

Clinical development of the GnRH agonist leuprolide acetate depot

Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density

Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study

Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation

A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata

Current and Emerging Medical Treatments for Uterine Fibroids

Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by Elagolix in Healthy Premenopausal Women

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies

Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire

Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial

Pre-eclampsia-like conditions produced by nitric oxide inhibition: effects of L-arginine, D-arginine and steroid hormones

Long-term Effect of Elagolix on Bone Mineral Density in Women with Endometriosis-Associated Pain [38G]

Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women

Modulation of the Action of Chorionic Gonadotropin in the Baboon (Papio anubis) Uterus by a Progesterone Receptor Antagonist (ZK 137.316)

The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis

Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain

Validation of the Menstrual Pictogram in Women With Leiomyomata Associated With Heavy Menstrual Bleeding

Long-Term Safety and Efficacy of Elagolix Treatment in Women With Endometriosis-Associated Pain [11OP]

Development and Validation of the Endometriosis Daily Pain Impact Diary Items to Assess Dysmenorrhea and Nonmenstrual Pelvic Pain

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