UB Paderborn / Katalog / Suche / in CDI

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1209-1214

2015

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Solid-Phase Azopeptide Diels–Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation

Journal of organic chemistry, 2019-05, Vol.84 (10), p.6006-6016

2019

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Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3777-3792

2016

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Novel µ opioid antagonists derived from the µ opioid agonists endomorphin and [Dmt1]DALDA (H‐Dmt‐D‐Arg‐Phe‐Lys‐NH2)

Chemical biology & drug design, 2020-11, Vol.96 (5), p.1305-1314

2020

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[Dmt1]DALDA analogues modified with tyrosine analogues at position 1

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3629-3631

2016

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Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice

ACS chemical neuroscience, 2017-10, Vol.8 (10), p.2315-2324

2017

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Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics

European journal of medicinal chemistry, 2015-03, Vol.92, p.64-77

2015

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[Dmt1]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2333-2338

2014

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Corrigendum to “Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings” [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320–2323]

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (20), p.3418-3418

2018

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A Cyclic Tetrapeptide (“Cyclodal”) and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9243-9254

2016

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‘Carba’-carfentanil (trans isomer): A μ opioid receptor (MOR) partial agonist with a distinct binding mode

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4581-4586

2014

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Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (13), p.2320-2323

2018

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Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1‑DALDA: Effect on Opioid Activity and Biodistribution

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9549-9561

2012

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Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9549

2012

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Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2467-2476

2011

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Cyclic Enkephalins with a Diversely Substituted Guanidine Bridge or a Thiourea Bridge: Synthesis, Biological and Structural Evaluations

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5964-5973

2013

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χ‑Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds

ACS medicinal chemistry letters, 2017-11, Vol.8 (11), p.1177-1182

2017

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"Carba"-analogues of fentanyl are opioid receptor agonists

Journal of medicinal chemistry, 2010-04, Vol.53 (7), p.2875-2881

2010

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Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr-c[d-Cys-Gly-Phe-d(or l)-Cys]NH2 Retain High Opioid Activity

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1414-1417

2007

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N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (18), p.5082-5085

2013

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Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1899-1902

2012

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Agonist vs Antagonist Behavior of δ Opioid Peptides Containing Novel Phenylalanine Analogues in Place of Tyr

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6941-6945

2009

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Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

Chemical biology & drug design, 2012-02, Vol.79 (2), p.186-193

2012

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Blood−Brain Barrier Penetration by Two Dermorphin Tetrapeptide Analogues: Role of Lipophilicity vs Structural Flexibility

Journal of medicinal chemistry, 2008-04, Vol.51 (8), p.2571-2574

2008

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Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt, d-2-Nal4]endomorphin-1 (Antanal-1) and [Dmt1, d-2-Nal4]endomorphin-2 (Antanal-2)

Journal of medicinal chemistry, 2007-02, Vol.50 (3), p.512-520

2007

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Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

Solid-Phase Azopeptide Diels–Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation

Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Novel µ opioid antagonists derived from the µ opioid agonists endomorphin and [Dmt1]DALDA (H‐Dmt‐D‐Arg‐Phe‐Lys‐NH2)

[Dmt1]DALDA analogues modified with tyrosine analogues at position 1

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics

[Dmt1]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile

Corrigendum to “Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings” [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320–2323]

A Cyclic Tetrapeptide (“Cyclodal”) and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists

‘Carba’-carfentanil (trans isomer): A μ opioid receptor (MOR) partial agonist with a distinct binding mode

Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings

Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt1‑DALDA: Effect on Opioid Activity and Biodistribution

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution

Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist

Cyclic Enkephalins with a Diversely Substituted Guanidine Bridge or a Thiourea Bridge: Synthesis, Biological and Structural Evaluations

χ‑Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds

"Carba"-analogues of fentanyl are opioid receptor agonists

Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr-c[d-Cys-Gly-Phe-d(or l)-Cys]NH2 Retain High Opioid Activity

N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists

Agonist vs Antagonist Behavior of δ Opioid Peptides Containing Novel Phenylalanine Analogues in Place of Tyr

Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

Blood−Brain Barrier Penetration by Two Dermorphin Tetrapeptide Analogues: Role of Lipophilicity vs Structural Flexibility

Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt, d-2-Nal4]endomorphin-1 (Antanal-1) and [Dmt1, d-2-Nal4]endomorphin-2 (Antanal-2)

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