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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4517-4527

2020

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Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4517-4527

2020

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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4355-4359

2003

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SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

Arteriosclerosis, thrombosis, and vascular biology, 2008-04, Vol.28 (4), p.665-671

2008

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Abstract B94: Discovery of and first disclosure of the clinical candidate AZD9291, a potent and selective third-generation EGFR inhibitor of both activating and T790M resistant mutations that spares the wild type form of the receptor

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B94-B94

2013

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Infrared spectrum and potential energy surface of He–CO

The Journal of chemical physics, 1994-07, Vol.101 (1), p.39-61

1994

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A reliable new potential energy surface for H2–Ar

The Journal of chemical physics, 1996-08, Vol.105 (7), p.2639-2653

1996

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Linewidths and shifts of very low temperature CO in He: A challenge for theory or experiment?

The Journal of chemical physics, 1996-09, Vol.105 (10), p.4005-4014

1996

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Corrigendum to “Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)”: [Bioorg. Med. Chem. Lett. 13 (2003) 4355]

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (11), p.2991-2991

2004

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Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4355-4359

2003

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Calculated rovibrational energy levels and infrared spectrum of He-C2H2

Molecular physics, 1992-09, Vol.77 (1), p.111-134

1992

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Calculated rovibrational energy levels and infrared spectrum of He-C 2 H 2

Molecular physics, 1992-09, Vol.77 (1), p.111-134

1992

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Angle and bond-length dependent C6 coefficients for H2 interacting with H, Li, Be and rare gas atoms

Theoretica Chimica Acta, 1992, Vol.82 (1-2), p.57-73

1992

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The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

Transforming Growth Factor-β in Cancer Therapy, Volume II, p.685-696

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7025-7048

2013

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Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9958-9970

2014

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Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4386-4402

2017

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Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.300-305

2016

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Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1118-1123

2016

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Correction to Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6459-6459

2017

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Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo

ACS medicinal chemistry letters, 2013-08, Vol.4 (8), p.800-805

2013

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Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.514-519

2016

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Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

MedChemComm, 2014-10, Vol.5 (10), p.1533-1539

2014

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Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

ACS medicinal chemistry letters, 2012-04, Vol.3 (4), p.278-283

2012

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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

Abstract B94: Discovery of and first disclosure of the clinical candidate AZD9291, a potent and selective third-generation EGFR inhibitor of both activating and T790M resistant mutations that spares the wild type form of the receptor

Infrared spectrum and potential energy surface of He–CO

A reliable new potential energy surface for H2–Ar

Linewidths and shifts of very low temperature CO in He: A challenge for theory or experiment?

Corrigendum to “Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)”: [Bioorg. Med. Chem. Lett. 13 (2003) 4355]

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)

Calculated rovibrational energy levels and infrared spectrum of He-C2H2

Calculated rovibrational energy levels and infrared spectrum of He-C 2 H 2

Angle and bond-length dependent C6 coefficients for H2 interacting with H, Li, Be and rare gas atoms

The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening

Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

Correction to Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

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