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Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol

Structure (London), 2007-08, Vol.15 (8), p.992-1004

2007

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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

The Journal of biological chemistry, 2014-02, Vol.289 (7), p.4432-4443

2014

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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

Molecular metabolism (Germany), 2018-06, Vol.12, p.12-24

2018

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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9728-9733

2013

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Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism

The Journal of nutrition, 2006, Vol.136 (1S), p.243S-249S

2006

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Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex

The Journal of biological chemistry, 2009-05, Vol.284 (19), p.13086-13098

2009

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Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

The Journal of biological chemistry, 2008-09, Vol.283 (37), p.25305-25315

2008

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Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

The EMBO journal, 2005-05, Vol.24 (10), p.1763-1774

2005

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Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

The Journal of biological chemistry, 2014-07, Vol.289 (30), p.20583-20593

2014

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Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1142-1150

2017

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Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

Structure (London), 2008-12, Vol.16 (12), p.1849-1859

2008

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Structure of Rat BCKD Kinase: Nucleotide-Induced Domain Communication in a Mitochondrial Protein Kinase

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (20), p.11218-11223

2001

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Structural Determinants for Cross-talk between Pyruvate Dehydrogenase Kinase 3 and Lipoyl Domain 2 of the Human Pyruvate Dehydrogenase Complex

The Journal of biological chemistry, 2006-09, Vol.281 (37), p.27197-27204

2006

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Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD +/NADH Binding and the Structural Basis of Disease-causing Mutations

Journal of molecular biology, 2005-07, Vol.350 (3), p.543-552

2005

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Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Analytical biochemistry, 2010-12, Vol.407 (1), p.89-103

2010

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Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex

Structure (London), 2006-03, Vol.14 (3), p.611-621

2006

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Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex

The Journal of biological chemistry, 2011-07, Vol.286 (26), p.23476-23488

2011

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A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain α-ketoacid dehydrogenase complex

The EMBO journal, 2006-12, Vol.25 (24), p.5983-5994

2006

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Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease

Structure (London), 2000-03, Vol.8 (3), p.277-291

2000

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A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

Structure (London), 2006-02, Vol.14 (2), p.287-298

2006

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Diagnosis and mutational analysis of maple syrup urine disease using cell cultures

Methods in Enzymology, 2000, Vol.324, p.413-423

2000

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Molecular Mechanism for Regulation of the Human Mitochondrial Branched-Chain α-Ketoacid Dehydrogenase Complex by Phosphorylation

Structure (London), 2004-12, Vol.12 (12), p.2185-2196

2004

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Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype

The Journal of biological chemistry, 2004-04, Vol.279 (17), p.17792-17800

2004

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The Two Active Sites in Human Branched-chain α-Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-site Mechanism

The Journal of biological chemistry, 2007-04, Vol.282 (16), p.11904-11913

2007

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Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

The Journal of biological chemistry, 2004-07, Vol.279 (31), p.32968-32978

2004

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Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism

Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

Structure of Rat BCKD Kinase: Nucleotide-Induced Domain Communication in a Mitochondrial Protein Kinase

Structural Determinants for Cross-talk between Pyruvate Dehydrogenase Kinase 3 and Lipoyl Domain 2 of the Human Pyruvate Dehydrogenase Complex

Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD +/NADH Binding and the Structural Basis of Disease-causing Mutations

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex

Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex

A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain α-ketoacid dehydrogenase complex

Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease

A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

Diagnosis and mutational analysis of maple syrup urine disease using cell cultures

Molecular Mechanism for Regulation of the Human Mitochondrial Branched-Chain α-Ketoacid Dehydrogenase Complex by Phosphorylation

Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype

The Two Active Sites in Human Branched-chain α-Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-site Mechanism

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

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