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Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5979-5983

2013

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

ACS medicinal chemistry letters, 2014-02, Vol.5 (2), p.124-127

2014

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Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9363-9375

2023

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Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase

Antimicrobial agents and chemotherapy, 2020-12, Vol.65 (1)

2020

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In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Molecular cancer therapeutics, 2006-11, Vol.5 (11), p.2644-2658

2006

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Total Synthesis of Vancomycin-Part 1: Design and Development of Methodology

Chemistry : a European journal, 1999-09, Vol.5 (9), p.2584-2601

1999

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Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Science translational medicine, 2019-05, Vol.11 (491)

2019

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Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

Bioorganic & medicinal chemistry, 2014-08, Vol.22 (15), p.4001-4009

2014

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Experimental Study on Emergency Reclaiming of Offshore Underwater Leakage Oil

Applied Mechanics and Materials, 2013-01, Vol.318, p.522-526

2013

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Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

Chemistry : a European journal, 1999-02, Vol.5 (2), p.599-617

1999

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Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1292-1297

2017

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Identification of novel, potent and selective inhibitors of Polo-like kinase 1

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1247-1250

2012

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Opportunities and Challenges of Developing Peptide Drugs in the Pharmaceutical Industry

Advances in experimental medicine and biology, 2009, Vol.611, p.467-469

2009

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A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (10), p.2671-2677

2004

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Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4910-4914

2005

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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.133-137

2003

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New Technology for the Synthesis of Vancomycin-Type Biaryl Ring Systems

Angewandte Chemie (International ed.), 1997-08, Vol.36 (13-14), p.1539-1540

1997

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Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis

Journal of hepatology, 2023-06, Vol.78, p.S784

2023

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WED-510 - Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis

Journal of hepatology, 2023-06, Vol.78, p.S784-S784

2023

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Erratum for Lu et al., “Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase”

Antimicrobial agents and chemotherapy, 2021-06, Vol.65 (7), p.e0082021-e0082021

2021

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Preparation of human Melanocortin-4 receptor agonist libraries : Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5504-5508

2005

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Total synthesis and structural revision of chromomoric acid D-I methyl ester

Tetrahedron, 1998-10, Vol.54 (41), p.12561-12570

1998

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Structure-activity relationship of cyclic peptide Penta-c[Asp-His6-DPhe7-Arg8-Trp9-Lys]-NH2 at the human melanocortin-1 and -4 receptors: His6 substitution

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1307-1311

2003

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Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis

Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Total Synthesis of Vancomycin-Part 1: Design and Development of Methodology

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

Experimental Study on Emergency Reclaiming of Offshore Underwater Leakage Oil

Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors

Identification of novel, potent and selective inhibitors of Polo-like kinase 1

Opportunities and Challenges of Developing Peptide Drugs in the Pharmaceutical Industry

A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution

New Technology for the Synthesis of Vancomycin-Type Biaryl Ring Systems

Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis

WED-510 - Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis

Erratum for Lu et al., “Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase”

Preparation of human Melanocortin-4 receptor agonist libraries : Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2

Total synthesis and structural revision of chromomoric acid D-I methyl ester

Structure-activity relationship of cyclic peptide Penta-c[Asp-His6-DPhe7-Arg8-Trp9-Lys]-NH2 at the human melanocortin-1 and -4 receptors: His6 substitution

The TB Drug Accelerator at Year Ten: What Have We Learned?

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