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SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Blood, 2017-12, Vol.130 (24), p.2631-2641

2017

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FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

Cell stem cell, 2012-09, Vol.11 (3), p.346-358

2012

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miR-99 regulates normal and malignant hematopoietic stem cell self-renewal

The Journal of experimental medicine, 2017-08, Vol.214 (8), p.2453-2470

2017

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MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

The Journal of clinical investigation, 2016-03, Vol.126 (3), p.997-1011

2016

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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Cancer discovery, 2020-02, Vol.10 (2), p.214-231

2020

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Mechanisms of resistance to FLT3 inhibitors

Drug resistance updates, 2009-02, Vol.12 (1), p.8-16

2009

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Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras

Blood advances, 2018-10, Vol.2 (19), p.2478-2490

2018

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Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

Nature (London), 2017-04, Vol.544 (7648), p.53-58

2017

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NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

Cancer cell, 2016-12, Vol.30 (6), p.863-878

2016

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Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

iScience, 2020-03, Vol.23 (3), p.100941-100941, Article 100941

2020

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Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition

Leukemia, 2024-07, Vol.38 (7), p.1581-1591

2024

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Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Cancer discovery, 2020-10, Vol.10 (10), p.1500-1513

2020

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Stem cells: Dual response to Ras mutation

Nature (London), 2013-12, Vol.504 (7478), p.91-92

2013

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Dual response to Ras mutation

Nature (London), 2013-12, Vol.504 (7478), p.91-92

2013

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Polyhydroxybutyrate-enhanced transformation of log-phase Escherichia coli

BioTechniques, 2004-09, Vol.37 (3), p.376-382

2004

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Myeloid progenitor cluster formation drives regenerative and leukemic myelopoiesis

Experimental hematology, 2016-09, Vol.44 (9), p.S79-S80

2016

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Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

Blood, 2020-11, Vol.136 (Supplement 1), p.47-47

2020

Volltextzugriff (PDF)

Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function

Blood, 2021-11, Vol.138 (Supplement 1), p.951-951

2021

Volltextzugriff (PDF)

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

Blood, 2016-12, Vol.128 (22), p.423-423

2016

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Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Blood, 2016-12, Vol.128 (22), p.1511-1511

2016

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Targeting the DNA Damage Response Pathway in MLL- rearranged B-Acute Lymphoblastic Leukemias

Blood, 2017-12, Vol.130, p.3880-3880

2017

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The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

Blood, 2018-11, Vol.132 (Supplement 1), p.511-511

2018

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Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Blood, 2019-11, Vol.134 (Supplement_1), p.109-109

2019

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SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

miR-99 regulates normal and malignant hematopoietic stem cell self-renewal

MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Mechanisms of resistance to FLT3 inhibitors

Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Stem cells: Dual response to Ras mutation

Dual response to Ras mutation

Polyhydroxybutyrate-enhanced transformation of log-phase Escherichia coli

Myeloid progenitor cluster formation drives regenerative and leukemic myelopoiesis

Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease

Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies

Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Targeting the DNA Damage Response Pathway in MLL- rearranged B-Acute Lymphoblastic Leukemias

The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

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