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Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

Journal of Virology, 2011-09, Vol.85 (17), p.9078-9089

2011

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Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies

PloS one, 2013-08, Vol.8 (8), p.e71196

2013

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Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3982-3985

2011

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Fluorinated nucleosides: Synthesis and biological implication

Journal of fluorine chemistry, 2008-09, Vol.129 (9), p.743-766

2008

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Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model

Antiviral research, 2010-06, Vol.86 (3), p.261-267

2010

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2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine–entecavir resistant triple mutant and its mechanism of action

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.503-506

2013

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Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.244-254

2003

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Synthesis of an Anti-hepatitis B Agent, 2′-Fluoro-6′-methylene-carbocyclic Adenosine (FMCA) and Its Phosphoramidate (FMCAP)

Journal of organic chemistry, 2019-01, Vol.84 (2), p.752-759

2019

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Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6328-6331

2011

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Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

Antimicrobial Agents and Chemotherapy, 2002-12, Vol.46 (12), p.3854-3860

2002

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Prodrug Strategies for the Development of β‑l‑5-((E)‑2-Bromovinyl)-1-((2S,4S)‑2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l‑BHDU) against Varicella Zoster Virus (VZV)

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.7038-7053

2023

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2′‐Fluoro‐6′‐methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti‐HBV agent, active against drug‐resistant HBV mutants

Medicinal research reviews, 2018-05, Vol.38 (3), p.977-1002

2018

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Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase

Nucleosides, nucleotides & nucleic acids, 2020-02, Vol.39 (1-3), p.52-68

2020

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In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase

Antimicrobial Agents and Chemotherapy, 2005-03, Vol.49 (3), p.1139-1144

2005

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Synthesis and Anti-HIV Activity of d- and l-Thietanose Nucleosides

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1635-1647

2006

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(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2601-2604

2010

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Probing the Molecular Mechanisms of AZT Drug Resistance Mediated by HIV-1 Reverse Transcriptase Using a Transient Kinetic Analysis

Biochemistry (Easton), 2003-07, Vol.42 (29), p.8831-8841

2003

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Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

Journal of Virology, 2003-10, Vol.77 (19), p.10689-10694

2003

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Biochemical Studies on the Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to 1-(β-d-Dioxolane)Thymine Triphosphate

Antimicrobial Agents and Chemotherapy, 2007-06, Vol.51 (6), p.2078-2084

2007

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Stereoselective Synthesis of 2′-Fluoro-6′-methylene Carbocyclic Adenosine via Vince Lactam

Journal of organic chemistry, 2014-05, Vol.79 (9), p.3917-3923

2014

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Molecular Modeling Approach to Understanding the Mode of Action of l-Nucleosides as Antiviral Agents

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.138-144

2001

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Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system

Bioorganic & medicinal chemistry, 2005-03, Vol.13 (5), p.1641-1652

2005

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Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4396-4399

2005

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In Vitro Selection of Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Decrease Susceptibility to (−)-β-d-Dioxolane-Guanosine and Suppress Resistance to 3′-Azido-3′-Deoxythymidine

Antimicrobial Agents and Chemotherapy, 2000-07, Vol.44 (7), p.1783-1788

2000

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A Stereoselective Synthesis of 4′‐α‐Fluoro‐methyl Carbocyclic Nucleoside Analogs

ChemistrySelect (Weinheim), 2023-07, Vol.8 (26), p.n/a

2023

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Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies

Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus

Fluorinated nucleosides: Synthesis and biological implication

Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model

2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine–entecavir resistant triple mutant and its mechanism of action

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

Synthesis of an Anti-hepatitis B Agent, 2′-Fluoro-6′-methylene-carbocyclic Adenosine (FMCA) and Its Phosphoramidate (FMCAP)

Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

Prodrug Strategies for the Development of β‑l‑5-((E)‑2-Bromovinyl)-1-((2S,4S)‑2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l‑BHDU) against Varicella Zoster Virus (VZV)

2′‐Fluoro‐6′‐methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti‐HBV agent, active against drug‐resistant HBV mutants

Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase

In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase

Synthesis and Anti-HIV Activity of d- and l-Thietanose Nucleosides

(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

Probing the Molecular Mechanisms of AZT Drug Resistance Mediated by HIV-1 Reverse Transcriptase Using a Transient Kinetic Analysis

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

Biochemical Studies on the Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to 1-(β-d-Dioxolane)Thymine Triphosphate

Stereoselective Synthesis of 2′-Fluoro-6′-methylene Carbocyclic Adenosine via Vince Lactam

Molecular Modeling Approach to Understanding the Mode of Action of l-Nucleosides as Antiviral Agents

Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system

Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks

In Vitro Selection of Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Decrease Susceptibility to (−)-β-d-Dioxolane-Guanosine and Suppress Resistance to 3′-Azido-3′-Deoxythymidine

A Stereoselective Synthesis of 4′‐α‐Fluoro‐methyl Carbocyclic Nucleoside Analogs

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