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Total Synthesis of Aigialomycin D: Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations

Organic letters, 2008-03, Vol.10 (5), p.811-814

2008

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Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions

Organic letters, 2007-02, Vol.9 (3), p.537-540

2007

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A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]triazolo[4,5‑c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.207-223

2018

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Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators

Journal of medicinal chemistry, 2023-02, Vol.66 (4), p.2877-2892

2023

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Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators

Journal of medicinal chemistry, 2023-02, Vol.66 (4), p.2877-2892

2023

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Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9181-9196

2020

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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3157-3163

2015

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1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.261-266

2019

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1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.261-266

2019

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P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders

Progress in Medicinal Chemistry, 2014, Vol.53, p.65-100

2014

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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

ACS chemical neuroscience, 2016-04, Vol.7 (4), p.490-497

2016

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Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.811-815

2013

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Azabenzthiazole inhibitors of leukotriene A4 hydrolase

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7504-7511

2012

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A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1 H -[1,2,3]triazolo[4,5- c ]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.207-223

2018

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I. Nickel-catalyzed reductive aldol reactions, II. Total synthesis of aigialomycin D

Chrovian, Christa C

2007

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I. Nickel-catalyzed reductive aldol reactions, II. Total synthesis of aigialomycin D

Chrovian, Christa C

2007

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Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions

ChemInform, 2007-06, Vol.38 (26), p.no-no

2007

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ChemInform Abstract: Total Synthesis of Aigialomycin D (V): Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations

ChemInform, 2008-07, Vol.39 (30), p.no-no

2008

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Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

Neuropsychopharmacology (New York, N.Y.), 2018-12, Vol.43 (13), p.2586-2596

2018

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Total Synthesis of Aigialomycin D: Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations

Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions

A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]triazolo[4,5‑c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators

Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators

Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators

1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators

P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders

Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase

Azabenzthiazole inhibitors of leukotriene A4 hydrolase

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1 H -[1,2,3]triazolo[4,5- c ]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

I. Nickel-catalyzed reductive aldol reactions, II. Total synthesis of aigialomycin D

I. Nickel-catalyzed reductive aldol reactions, II. Total synthesis of aigialomycin D

Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions

ChemInform Abstract: Total Synthesis of Aigialomycin D (V): Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

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