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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

Translational psychiatry, 2020-09, Vol.10 (1), p.308-308, Article 308

2020

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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

The Journal of pharmacology and experimental therapeutics, 2015-03, Vol.352 (3), p.590-601

2015

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Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation

Sleep (New York, N.Y.), 2005-04, Vol.28 (4), p.395-409

2005

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Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

The Journal of pharmacology and experimental therapeutics, 2015-09, Vol.354 (3), p.471-482

2015

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Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.142-151

2009

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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

The Journal of pharmacology and experimental therapeutics, 2020-03, Vol.372 (3), p.339-353

2020

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Altered sleep regulation in leptin-deficient mice

American journal of physiology. Regulatory, integrative and comparative physiology, 2006-04, Vol.290 (4), p.R894-R903

2006

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Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.690-698

2007

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Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder

The Journal of pharmacology and experimental therapeutics, 2012-08, Vol.342 (2), p.429-440

2012

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Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Frontiers in pharmacology, 2017-06, Vol.8, p.357-357

2017

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Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope

PloS one, 2014-11, Vol.9 (11), p.e112068-e112068

2014

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Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function

Sleep (New York, N.Y.), 2006-09, Vol.29 (9), p.1211-1223

2006

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Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Frontiers in behavioral neuroscience, 2017-05, Vol.11, p.83-83

2017

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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

Psychopharmacologia, 2011-04, Vol.214 (4), p.829-841

2011

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Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Molecular pharmacology, 2002-08, Vol.62 (2), p.389

2002

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Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor

European journal of pharmacology, 2007-12, Vol.576 (1-3), p.43-54

2007

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Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines

European journal of medicinal chemistry, 2009-10, Vol.44 (10), p.4098-4106

2009

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Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression

Neuroreport, 2000-02, Vol.11 (3), p.627-631

2000

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

The Journal of pharmacology and experimental therapeutics, 2016-05, Vol.357 (2), p.394

2016

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Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models

European journal of pharmacology, 2020-09, Vol.882, p.173256-173256, Article 173256

2020

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GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine

Molecular pharmacology, 2015-11, Vol.88 (5), p.911-925

2015

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S170. In Vivo Characterization of an Orally Available, Brain Penetrant Small Molecule GPR139 Agonist

Biological psychiatry (1969), 2018-05, Vol.83 (9), p.S414-S414

2018

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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Frontiers in neuroscience, 2014-02, Vol.8, p.28-28

2014

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Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate

Journal of medicinal chemistry, 2015-07, Vol.58 (14), p.5620-5636

2015

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Functional activity of 5‐HT2 receptors in the modulation of the sleep/wakefulness states

Journal of sleep research, 1992-09, Vol.1 (3), p.163-168

DUGOVIC, CHRISTINE

1992

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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

Altered sleep regulation in leptin-deficient mice

Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents

Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope

Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor

Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines

Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine

S170. In Vivo Characterization of an Orally Available, Brain Penetrant Small Molecule GPR139 Agonist

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate

Functional activity of 5‐HT2 receptors in the modulation of the sleep/wakefulness states

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