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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2021-09, Vol.47, p.128168-128168, Article 128168

2021

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (13), p.5378-5383

2011

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (13), p.127197-127197, Article 127197

2020

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Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127367-127367, Article 127367

2020

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Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4709-4729

2021

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Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV‑1 Protein for Clearance

ACS medicinal chemistry letters, 2020-07, Vol.11 (7), p.1476-1483

2020

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (11), p.1380-1385

2019

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A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production

Assay and drug development technologies, 2008-06, Vol.6 (3), p.361-374

2008

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1182-1186

2019

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

ACS medicinal chemistry letters, 2014-10, Vol.5 (10), p.1082-1087

2014

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Discovery and optimization of novel 4-[(aminocarbonyl)amino]- N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6237-6240

2009

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3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4620-4623

2006

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

ACS medicinal chemistry letters, 2013-08, Vol.4 (8), p.773-778

2013

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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3983-3987

2003

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Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core

Protein expression and purification, 2004-06, Vol.35 (2), p.225-236

2004

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A Continuous Fluorescence Assay of Renin Activity

Analytical biochemistry, 1993-05, Vol.210 (2), p.351-359

1993

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Characterization of recombinant human renin : kinetics, pH-stability, and peptidomimetic inhibitor binding

Journal of protein chemistry, 1991-10, Vol.10 (5), p.553-563

1991

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Recombinant human prorenin from CHO cells : expression and purification

Journal of protein chemistry, 1990-12, Vol.9 (6), p.663-672

1990

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Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview

European spine journal, 2018-11, Vol.27 (11), p.2791-2803

2018

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Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials

BMJ (Online), 2015-03, Vol.350 (mar31 2), p.h1225-h1225

2015

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Surgical versus non-surgical treatment for sciatica: systematic review and meta-analysis of randomised controlled trials

BMJ (Online), 2023-04, Vol.381, p.e070730

2023

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Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)

Journal of clinical oncology, 2018-05, Vol.36 (14), p.1412-1418

2018

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Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Diabetes care, 2020-07, Vol.43 (7), p.1617-1635

2020

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The Effect of Galaxy Interactions on Molecular Gas Properties

The Astrophysical journal, 2018-12, Vol.868 (2), p.132

2018

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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir

Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity

Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV‑1 Protein for Clearance

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

Discovery and optimization of novel 4-[(aminocarbonyl)amino]- N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core

A Continuous Fluorescence Assay of Renin Activity

Characterization of recombinant human renin : kinetics, pH-stability, and peptidomimetic inhibitor binding

Recombinant human prorenin from CHO cells : expression and purification

Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials

Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview

Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials

Surgical versus non-surgical treatment for sciatica: systematic review and meta-analysis of randomised controlled trials

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)

Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The Effect of Galaxy Interactions on Molecular Gas Properties

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