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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Biochemical journal, 2009-06, Vol.421 (1), p.29-42

2009

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Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition

International journal of cancer, 2014-02, Vol.134 (3), p.552-562

2014

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Molecular cancer therapeutics, 2015-11, Vol.14 (11), p.2508-2518

2015

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Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

BMC medical genomics, 2012-12, Vol.5 (1), p.66-66, Article 66

2012

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Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim

PloS one, 2010-09, Vol.5 (9), p.e13026

2010

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Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (7), p.1804-1813

2012

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High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)

Cancer biology & therapy, 2009-11, Vol.8 (21), p.2073-2080

2009

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

Cancer research (Chicago, Ill.), 2010, Vol.70 (1), p.288-298

2010

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Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio

Cancer research (Chicago, Ill.), 1996-04, Vol.56 (8), p.1834-1841

1996

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Design and campaign synthesis of pyridine-based histone deacetylase inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2525-2529

2008

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Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2580-2584

2008

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MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells

Molecular pharmacology, 2001-01, Vol.59 (1), p.135-143

2001

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Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines

Cancer research (Chicago, Ill.), 1991-12, Vol.51 (24), p.6592-6595

1991

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Abstract 5559: Reciprocal expression of miR-125b and miR-192/miR-200 families define clinically relevant sub-types of colorectal cancer with differential sensitivity to EGFR and MEK targeted agents

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5559-5559

2014

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Oddball p53 in testicular tumors

Nature medicine, 1996-07, Vol.2 (7), p.745-746

1996

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Abstract LB-455: Reciprocal expression of miR125b and miR192/miR200 families define three clinically relevant sub-types of colorectal cancer with differential sensitivity to EGFR and MEK targeted agents

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.LB-455-LB-455

2012

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Abstract 5365: Molecular and pharmacological (EGFRi, MEKi) characterisation of a colorectal cancer (CRC) cell line panel to evaluate cellular phenotype and efficacy of targeted therapies in CRC

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.5365-5365

2011

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Abstract C135: AZ’4425 is a potent, selective, and orally bio-available progesterone receptor antagonist that has shown anti-tumor activity and inhibition of cancer stem cell proliferation

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C135-C135

2013

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Association of colorectal cancer intrinsic subtypes with prognosis, chemotherapy response, deficient mismatch repair, and epithelial to mesenchymal transition (EMT)

Journal of clinical oncology, 2013-02, Vol.31 (4_suppl), p.333-333

2013

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Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.917-917

2012

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Abstract 2995: Identifying subtypes of colorectal cancer tumors and cell lines with treatment relevance using iterative clustering (iNMF)

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2995-2995

2012

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Use of colorectal cancer subtypes identified through iterative clustering to predict response to therapy

Journal of clinical oncology, 2012-02, Vol.30 (4_suppl), p.482-482

2012

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Apoptosis: its relevance to carcinogenesis and anti-tumour drug sensitivity

Urolithiasis, 1999, Vol.27 (1), p.1-2

1999

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Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

Oncogene, 1999-02, Vol.18 (7), p.1457-1464

1999

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Depletion of cellular glutathione by N',N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea as a determinant of sensitivity of K562 human leukemia cells to 4-hydroperoxycyclophosphamide

Cancer research (Chicago, Ill.), 1990-07, Vol.50 (13), p.4067-4071

1990

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim

Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio

Design and campaign synthesis of pyridine-based histone deacetylase inhibitors

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines

Abstract 5559: Reciprocal expression of miR-125b and miR-192/miR-200 families define clinically relevant sub-types of colorectal cancer with differential sensitivity to EGFR and MEK targeted agents

Oddball p53 in testicular tumors

Abstract LB-455: Reciprocal expression of miR125b and miR192/miR200 families define three clinically relevant sub-types of colorectal cancer with differential sensitivity to EGFR and MEK targeted agents

Abstract 5365: Molecular and pharmacological (EGFRi, MEKi) characterisation of a colorectal cancer (CRC) cell line panel to evaluate cellular phenotype and efficacy of targeted therapies in CRC

Abstract C135: AZ’4425 is a potent, selective, and orally bio-available progesterone receptor antagonist that has shown anti-tumor activity and inhibition of cancer stem cell proliferation

Association of colorectal cancer intrinsic subtypes with prognosis, chemotherapy response, deficient mismatch repair, and epithelial to mesenchymal transition (EMT)

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Abstract 2995: Identifying subtypes of colorectal cancer tumors and cell lines with treatment relevance using iterative clustering (iNMF)

Use of colorectal cancer subtypes identified through iterative clustering to predict response to therapy

Apoptosis: its relevance to carcinogenesis and anti-tumour drug sensitivity

Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

Depletion of cellular glutathione by N',N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea as a determinant of sensitivity of K562 human leukemia cells to 4-hydroperoxycyclophosphamide

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