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Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (18), p.4970-4975

2016

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Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

Cancer research (Chicago, Ill.), 2014-03, Vol.74 (5), p.1506-1517

2014

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Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

Molecular endocrinology (Baltimore, Md.), 2011-12, Vol.25 (12), p.2041-2053

2011

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A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis

The Journal of biological chemistry, 2015-04, Vol.290 (16), p.10382-10394

2015

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Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

Cancer cell, 2015-08, Vol.28 (2), p.240-252

2015

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Structural Basis for Different Substrate Profiles of Two Closely Related Class D β‑Lactamases and Their Inhibition by Halogens

Biochemistry (Easton), 2015-06, Vol.54 (21), p.3370-3380

2015

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Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

PloS one, 2014-04, Vol.9 (4), p.e95243

2014

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Probing the sites of interactions of rotaviral proteins involved in replication

Journal of virology, 2014-11, Vol.88 (21), p.12866-12881

2014

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BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3398-3401

2013

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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

PloS one, 2011-04, Vol.6 (4), p.e18413-e18413

2011

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Identification of the β-Lactamase Inhibitor Protein-II (BLIP-II) Interface Residues Essential for Binding Affinity and Specificity for Class A β-Lactamases

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17156-17166

2013

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Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA

PloS one, 2015-02, Vol.10 (2), p.e0116318-e0116318

2015

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Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5′ GG Sequence for RTPase Activity

Journal of Virology, 2012-10, Vol.86 (19), p.10547-10557

2012

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Identification of a β-Lactamase Inhibitory Protein Variant That Is a Potent Inhibitor of Staphylococcus PC1 β-Lactamase

Journal of molecular biology, 2011-03, Vol.406 (5), p.730-744

2011

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Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

Molecular cell, 2003-12, Vol.12 (6), p.1367-1378

2003

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Engineering Specificity from Broad to Narrow: Design of a β‑Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β‑Lactamase

ACS infectious diseases, 2016-12, Vol.2 (12), p.969-979

2016

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Analysis of the Binding Forces Driving the Tight Interactions between β-Lactamase Inhibitory Protein-II (BLIP-II) and Class A β-Lactamases

The Journal of biological chemistry, 2011-09, Vol.286 (37), p.32723-32735

2011

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Thermodynamic Investigation of the Role of Contact Residues of β-Lactamase-inhibitory Protein for Binding to TEM-1 β-Lactamase

The Journal of biological chemistry, 2007-06, Vol.282 (24), p.17676-17684

2007

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Disruption of Mitochondrial Networks by the Human Cytomegalovirus UL37 Gene Product Viral Mitochondrion-Localized Inhibitor of Apoptosis

Journal of Virology, 2003-01, Vol.77 (1), p.631-641

2003

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Fine Mapping of the Sequence Requirements for Binding of β-Lactamase Inhibitory Protein (BLIP) to TEM-1 β-Lactamase Using a Genetic Screen for BLIP Function

Journal of molecular biology, 2009-06, Vol.389 (2), p.401-412

2009

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Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex

Science (American Association for the Advancement of Science), 2001-03, Vol.291 (5511), p.2150-2155

2001

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Molecular Mechanisms for Viral Mimicry of a Human Cytokine: Activation of gp130 by HHV-8 Interleukin-6

Journal of molecular biology, 2004-01, Vol.335 (2), p.641-654

2004

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MalE of Group A Streptococcus Participates in the Rapid Transport of Maltotriose and Longer Maltodextrins

Journal of Bacteriology, 2007-04, Vol.189 (7), p.2610-2617

2007

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Functional significance of the beta-subunit for heterodimeric P-type ATPases

Journal of experimental biology, 1995-01, Vol.198 (Pt 1), p.1-17

1995

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Thermodynamic Analysis of the Binding of Oxidized and Reduced FMN Cofactor to Vibrio harveyi NADPH-FMN Oxidoreductase FRP Apoenzyme

Biochemistry (Easton), 2006-12, Vol.45 (49), p.14781-14787

2006

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Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

Structural Basis for Different Substrate Profiles of Two Closely Related Class D β‑Lactamases and Their Inhibition by Halogens

Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

Probing the sites of interactions of rotaviral proteins involved in replication

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

Identification of the β-Lactamase Inhibitor Protein-II (BLIP-II) Interface Residues Essential for Binding Affinity and Specificity for Class A β-Lactamases

Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5′ GG Sequence for RTPase Activity

Identification of a β-Lactamase Inhibitory Protein Variant That Is a Potent Inhibitor of Staphylococcus PC1 β-Lactamase

Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

Engineering Specificity from Broad to Narrow: Design of a β‑Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β‑Lactamase

Analysis of the Binding Forces Driving the Tight Interactions between β-Lactamase Inhibitory Protein-II (BLIP-II) and Class A β-Lactamases

Thermodynamic Investigation of the Role of Contact Residues of β-Lactamase-inhibitory Protein for Binding to TEM-1 β-Lactamase

Disruption of Mitochondrial Networks by the Human Cytomegalovirus UL37 Gene Product Viral Mitochondrion-Localized Inhibitor of Apoptosis

Fine Mapping of the Sequence Requirements for Binding of β-Lactamase Inhibitory Protein (BLIP) to TEM-1 β-Lactamase Using a Genetic Screen for BLIP Function

Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex

Molecular Mechanisms for Viral Mimicry of a Human Cytokine: Activation of gp130 by HHV-8 Interleukin-6

MalE of Group A Streptococcus Participates in the Rapid Transport of Maltotriose and Longer Maltodextrins

Functional significance of the beta-subunit for heterodimeric P-type ATPases

Thermodynamic Analysis of the Binding of Oxidized and Reduced FMN Cofactor to Vibrio harveyi NADPH-FMN Oxidoreductase FRP Apoenzyme

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