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Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N -Acetylgalactosamine-Conjugated RNA Interference Therapeutic

Drug metabolism and disposition, 2021-07, Vol.49 (7), p.572-580

2021

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Chitosan oligosaccharide–arachidic acid-based nanoparticles for anti-cancer drug delivery

International journal of pharmaceutics, 2013-01, Vol.441 (1-2), p.373-380

2013

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Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet

Journal of agricultural and food chemistry, 2016-07, Vol.64 (27), p.5598-5606

2016

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In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism

Planta medica, 2014-05, Vol.80 (7), p.561

2014

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PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) Modulates Eosinophil Chemotaxis by Regulating CCL26 Expression from Epithelial Cells

PloS one, 2016-03, Vol.11 (3), p.e0151758-e0151758

2016

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Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

Archives of pharmacal research, 2003-09, Vol.26 (9), p.768-772

2003

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Enhanced metabolism of indinavir and formation of M6, the major metabolite, by the co-administration of HM-30181, a selective p-glycoprotein inhibitor

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S92-S92

2017

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Comparison of saline vs. blood replenishment after blood sampling in a rat pharmacokinetic study

Journal of Pharmaceutical Investigation, 2019, 49(5), , pp.543-551

2019

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Induction of heme oxygenase-1 (HO-1) and NAD[P]H : Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert -butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes

Pharmaceutical research, 2006-11, Vol.23 (11), p.2586-2594

2006

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Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

Pharmaceutical research, 2003-03, Vol.20 (3), p.397-405

2003

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Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Journal of pharmaceutical sciences, 2005-02, Vol.94 (2), p.233-239

2005

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Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds

International journal of pharmaceutics, 2005-06, Vol.297 (1), p.235-241

2005

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Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery

European journal of pharmaceutics and biopharmaceutics, 2004-07, Vol.58 (1), p.99-105

2004

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In silico prediction of biliary excretion of drugs in rats based on physicochemical properties

Drug metabolism and disposition, 2010-03, Vol.38 (3), p.422

2010

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Functional Consequences of Genetic Variations in the Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) in the Korean Population

Journal of pharmaceutical sciences, 2012-03, Vol.101 (3), p.1302-1313

2012

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Lack of a Primary Physicochemical Determinant in the Direct Transport of Drugs to the Brain after Nasal Administration in Rats: Potential Involvement of Transporters in the Pathway

DRUG METABOLISM AND PHARMACOKINETICS, 2010-01, Vol.25 (5), p.430-441

2010

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1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression

Immune Network, 2015, 15(2), , pp.100-109

2015

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A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation

Colloids and surfaces, B, Biointerfaces, 2012-04, Vol.92, p.299-304

2012

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Nature biotechnology, 2022-10, Vol.40 (10), p.1500-1508

2022

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A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma

Journal of pharmaceutical and biomedical analysis, 2003-08, Vol.32 (6), p.1189-1197

2003

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In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1183-1194

2019

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Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Immune Functions in Healthy Adults in a Randomized Controlled Trial

Immune Network, 2015, 15(3), , pp.150-160

2015

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P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

Cancer chemotherapy and pharmacology, 2005-02, Vol.55 (2), p.110-116

2005

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Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N -Acetylgalactosamine-Conjugated RNA Interference Therapeutic

Chitosan oligosaccharide–arachidic acid-based nanoparticles for anti-cancer drug delivery

Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet

In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism

PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) Modulates Eosinophil Chemotaxis by Regulating CCL26 Expression from Epithelial Cells

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

Enhanced metabolism of indinavir and formation of M6, the major metabolite, by the co-administration of HM-30181, a selective p-glycoprotein inhibitor

Comparison of saline vs. blood replenishment after blood sampling in a rat pharmacokinetic study

Induction of heme oxygenase-1 (HO-1) and NAD[P]H : Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert -butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery

In silico prediction of biliary excretion of drugs in rats based on physicochemical properties

Functional Consequences of Genetic Variations in the Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) in the Korean Population

Lack of a Primary Physicochemical Determinant in the Direct Transport of Drugs to the Brain after Nasal Administration in Rats: Potential Involvement of Transporters in the Pathway

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression

A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation

Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma

In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters

Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Immune Functions in Healthy Adults in a Randomized Controlled Trial

Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

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