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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Science (American Association for the Advancement of Science), 1995-05, Vol.268 (5211), p.726-731

1995

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YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non-Small Cell Lung Cancer

Clinical cancer research, 2019-04, Vol.25 (8), p.2575-2587

2019

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Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5535-5550

2021

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Efficient Assembly of the Phomactin Core via Two Different Macrocyclization Protocols

Organic letters, 2001-11, Vol.3 (23), p.3615-3617

2001

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LPU: A Latency-Optimized and Highly Scalable Processor for Large Language Model Inference

IEEE MICRO, 2024-07, p.1-12

2024

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SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor

European journal of medicinal chemistry, 2022-12, Vol.244, p.114826-114826, Article 114826

2022

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Abstract 3915: YH25248, a selective PI3K delta inhibitor, shows synergistic effect with an anti-PD-L1 antibody

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3915-3915

2019

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Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6070-6085

2016

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Development of a novel glucosylceramide synthase (GCS) inhibitor with increased blood-brain barrier penetration for treatment of Gaucher disease

Molecular genetics and metabolism, 2019-02, Vol.126 (2), p.S21-S21

2019

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Abstract 5990: Microtubule-associated serine/threonine kinase-likeinhibitor, AD1208, as a novel cancer therapeutics

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5990-5990

2024

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SAT-350-YH25724, a novel long-acting GLP-1/FGF21 dual agonist, exhibits marked anti-fibrotic effects in different experimental models of liver fibrosis

Journal of hepatology, 2019-04, Vol.70 (1), p.e793-e793

2019

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Abstract 4790: YH25448, an irreversible 3rd generation EGFR TKI, exhibits superior anticancer effects with potent brain BBB penetration in NSCLC

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4790-4790

2018

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Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications

Current topics in medicinal chemistry, 2002-09, Vol.2 (9), p.915-938

2002

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YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.9033-9033

2018

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Abstract 2529: Optimization of small molecules targeting BMI1 protein expression. Part 1. Amino-thiazoles: the first-in-class highly potent inhibitors of BMI1 protein

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2529-2529

2014

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Highly enantioselective routes to darzens and acetate aldol products from achiral aldehydes and t-butyl bromoacetate

Tetrahedron letters, 1991-06, Vol.32 (25), p.2857-2860

1991

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The Impact of Internal Market Orientation on Organizational Citizenship Behavior and Innovative Behavior through Organizational Identification : The Moderating Effect of Psychological Contract Breach

The Korean Academic Association of Business Administration, 2022-09, Vol.35 (9), p.1787-1817

2022

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An enantioselective synthesis of ( 6R)-lactacystin

Tetrahedron letters, 1993-10, Vol.34 (44), p.6969-6972

1993

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An enantioselective synthesis of ( 2S, 3S)- and ( 2R, 3S)-3-hydroxyleucine

Tetrahedron letters, 1992-11, Vol.33 (45), p.6735-6738

1992

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Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.673-678

2007

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4965-4968

2006

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Efficient enantioselective syntheses of chloramphenicol and ( d) -threo- and ( d)- erythro-sphingosine

Tetrahedron letters, 2000-04, Vol.41 (16), p.2765-2768

2000

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Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2706-2711

2007

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3053-3057

2005

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Chiral diazaborolidine-mediated enantioselective aldol reactions of phenylthioacetate esters

Tetrahedron letters, 2000-04, Vol.41 (16), p.2769-2772

2000

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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non-Small Cell Lung Cancer

Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy

Efficient Assembly of the Phomactin Core via Two Different Macrocyclization Protocols

LPU: A Latency-Optimized and Highly Scalable Processor for Large Language Model Inference

SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor

Abstract 3915: YH25248, a selective PI3K delta inhibitor, shows synergistic effect with an anti-PD-L1 antibody

Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

Development of a novel glucosylceramide synthase (GCS) inhibitor with increased blood-brain barrier penetration for treatment of Gaucher disease

Abstract 5990: Microtubule-associated serine/threonine kinase-likeinhibitor, AD1208, as a novel cancer therapeutics

SAT-350-YH25724, a novel long-acting GLP-1/FGF21 dual agonist, exhibits marked anti-fibrotic effects in different experimental models of liver fibrosis

Abstract 4790: YH25448, an irreversible 3rd generation EGFR TKI, exhibits superior anticancer effects with potent brain BBB penetration in NSCLC

Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications

YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results

Abstract 2529: Optimization of small molecules targeting BMI1 protein expression. Part 1. Amino-thiazoles: the first-in-class highly potent inhibitors of BMI1 protein

Highly enantioselective routes to darzens and acetate aldol products from achiral aldehydes and t-butyl bromoacetate

The Impact of Internal Market Orientation on Organizational Citizenship Behavior and Innovative Behavior through Organizational Identification : The Moderating Effect of Psychological Contract Breach

An enantioselective synthesis of ( 6R)-lactacystin

An enantioselective synthesis of ( 2S, 3S)- and ( 2R, 3S)-3-hydroxyleucine

Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

Efficient enantioselective syntheses of chloramphenicol and ( d) -threo- and ( d)- erythro-sphingosine

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR

Chiral diazaborolidine-mediated enantioselective aldol reactions of phenylthioacetate esters

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