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Structural basis for RNA replication by the hepatitis C virus polymerase

Science (American Association for the Advancement of Science), 2015-02, Vol.347 (6223), p.771-775

2015

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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

PLoS pathogens, 2012-11, Vol.8 (11), p.e1003030

2012

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Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.1943-1951

2014

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Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.1930-1942

2014

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Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates

Tetrahedron letters, 2012-05, Vol.53 (18), p.2360-2363

2012

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Evolution of HCV NS5B Nucleoside and Nucleotide Inhibitors

HCV: The Journey from Discovery to a Cure, p.117-139

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Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1812-1825

2014

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Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2705-2707

2012

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Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability

Antimicrobial agents and chemotherapy, 2024-04, Vol.68 (4), p.e0137323-e0137323

2024

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Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

Tetrahedron letters, 2012-02, Vol.53 (5), p.484-486

2012

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Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4127-4132

2012

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Preparation and biological evaluation of 1′-cyano-2′-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2014-07, Vol.24 (14), p.3092-3095

2014

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Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (8), p.1840-1847

2017

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Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1394-1396

2012

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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2629-2634

2012

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Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (5), p.1040-1043

2015

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Practical synthesis of 1&; prime; -substituted Tubercidin C-nucleoside analogs

Tetrahedron letters, 2012-02, Vol.53 (5), p.484-486

2012

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Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

Nucleosides, nucleotides & nucleic acids, 2015-11, Vol.34 (11), p.763-785

2015

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Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3568-3572

2011

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Synthesis and antiviral activity of a series of 1a2-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2705-2707

2012

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Synthesis and characterization of 2a2-C-Me branched C-nucleosides as HCV polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4127-4132

2012

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Discovery of RWJ-54428 (MC-02, 479), a New Cephalosporin Active Against Resistant Gram-positive Bacteria

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1272-1281

2000

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Recent Advances in Oral Prodrug Discovery

Annual Reports in Medicinal Chemistry, 2006, Vol.41, p.395-407

Cho, Aesop

2006

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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.475-479

2004

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Structural basis for RNA replication by the hepatitis C virus polymerase

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates

Evolution of HCV NS5B Nucleoside and Nucleotide Inhibitors

Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors

Preparation and biological evaluation of 1′-cyano-2′-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

Synthesis and characterization of 1′-C-cyano-2′-fluoro-2′-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors

Practical synthesis of 1&; prime; -substituted Tubercidin C-nucleoside analogs

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease

Synthesis and antiviral activity of a series of 1a2-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Synthesis and characterization of 2a2-C-Me branched C-nucleosides as HCV polymerase inhibitors

Discovery of RWJ-54428 (MC-02, 479), a New Cephalosporin Active Against Resistant Gram-positive Bacteria

Recent Advances in Oral Prodrug Discovery

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

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