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Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Cellular signalling, 2014-02, Vol.26 (2), p.323-331

2014

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Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

Molecular biology of the cell, 2014-04, Vol.25 (7), p.1159-1170

2014

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Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Diabetes (New York, N.Y.), 2013-04, Vol.62 (4), p.1139-1151

2013

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Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Cellular signalling, 2011-10, Vol.23 (10), p.1546-1554

2011

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Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

Biochemical pharmacology, 2014-11, Vol.92 (2), p.380-388

2014

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NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Endocrinology (Philadelphia), 2010-12, Vol.151 (12), p.5624-5637

2010

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Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

American Journal of Physiology: Cell Physiology, 2014-05, Vol.306 (10), p.C879-C886

2014

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Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Cell communication and signaling, 2012-10, Vol.10 (1), p.30-30, Article 30

2012

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The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action

Proceedings of the National Academy of Sciences - PNAS, 2023-07, Vol.120 (27), p.e2211041120-e2211041120

2023

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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Journal of Virology, 2012-11, Vol.86 (21), p.11595-11607

2012

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Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Molecular biology of the cell, 2012-10, Vol.23 (20), p.4065-4078

2012

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Influence of fin size and distribution on solid-liquid phase change in a rectangular enclosure

International journal of thermal sciences, 2018-02, Vol.124, p.433-446

2018

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Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells

Molecular biology of the cell, 2010-10, Vol.21 (20), p.3529-3539

2010

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Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17520-17531

2013

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THE PRE-MERGER IMPACT VELOCITY OF THE BINARY CLUSTER A1750 FROM X-RAY, LENSING, AND HYDRODYNAMICAL SIMULATIONS

The Astrophysical journal, 2013-11, Vol.779 (1), p.63

2013

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A Phase 1/2 first-in-human study to evaluate the safety, tolerability, and pharmacokinetics of UX053 in patients with glycogen storage disease type III

Molecular genetics and metabolism, 2024-04, Vol.141 (4), p.108250, Article 108250

2024

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Structure–Activity Relationships and Discovery of (S)‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6H‑pyrido[1,2‑h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.1421-1446

2024

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Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.1421-1446

2024

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HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element

Antiviral research, 2018-01, Vol.149, p.191-201

2018

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Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506

Bioorganic & medicinal chemistry letters, 2023-10, Vol.94, p.129456-129456, Article 129456

2023

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Insulin‐stimulated PAK1 activation is required for glucose uptake in skeletal muscle cells (797.1)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

Antiviral research, 2022-01, Vol.197, p.105211-105211, Article 105211

2022

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The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

RSC medicinal chemistry, 2022-03, Vol.13 (3), p.343-349

2022

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AMCP Partnership Forum: Driving Value and Outcomes in Oncology

Journal of managed care & specialty pharmacy, 2018-06, Vol.24 (6), p.572

2018

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Racl Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle

Diabetes (New York, N.Y.), 2013, Vol.62 (4), p.1139-1151

2013

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Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action

Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Influence of fin size and distribution on solid-liquid phase change in a rectangular enclosure

Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells

Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance

THE PRE-MERGER IMPACT VELOCITY OF THE BINARY CLUSTER A1750 FROM X-RAY, LENSING, AND HYDRODYNAMICAL SIMULATIONS

A Phase 1/2 first-in-human study to evaluate the safety, tolerability, and pharmacokinetics of UX053 in patients with glycogen storage disease type III

Structure–Activity Relationships and Discovery of (S)‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6H‑pyrido[1,2‑h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element

Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506

Insulin‐stimulated PAK1 activation is required for glucose uptake in skeletal muscle cells (797.1)

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

AMCP Partnership Forum: Driving Value and Outcomes in Oncology

Racl Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle

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