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Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1407-1411

2013

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PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA

Molecular therapy, 2021-03, Vol.29 (3), p.1086-1101

2021

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A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys

The Journal of pharmacology and experimental therapeutics, 2010-10, Vol.335 (1), p.103

2010

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.63-68

2013

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Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1079-1084

2013

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Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

Diabetes (New York, N.Y.), 2000-12, Vol.49 (12), p.2079-2086

2000

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Pharmacological Characterization of Human, Monkey and Rat MT1 and MT2 Receptors

The FASEB journal, 2011-04, Vol.25, p.626.8-626.8

2011

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Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6338-6347

1993

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Galanin function in the central nervous system

Current opinion in drug discovery & development, 2006-09, Vol.9 (5), p.560

2006

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Cell, 1986-11, Vol.47 (3), p.381-389

1986

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Optimization of triazole-based TGR5 agonists towards orally available agentsElectronic supplementary information (ESI) available: Detailed experimental procedures for synthesis of compounds 4, 10-18, a dataset of compounds 2-9 used for a plot in Fig. 2, and protocols for cAMP assays, human whole blood assay, and in vivo dog PK studies. See DOI: 10.1039/c2md20174g

2012-12

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DNA Polymorphism of the C4 Genes: A New Marker for Analysis of the Major Histocompatibility Complex

The New England journal of medicine, 1984-01, Vol.310 (2), p.88-91

1984

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Isolation of Human mdr DNA Sequences Amplified in Multidrug-Resistant KB Carcinoma Cells

Proceedings of the National Academy of Sciences - PNAS, 1986-06, Vol.83 (12), p.4538-4542

1986

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Evidence for hybrid rodent and human insulin receptors in transfected cells

The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15587-15590

1991

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Substrates and signalling complexes: The tortured path to insulin action

Journal of cellular biochemistry, 1992-01, Vol.48 (1), p.12-18

1992

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Structure and Expression of the Human MDR (P-Glycoprotein) Gene Family

Molecular and cellular biology, 1989-09, Vol.9 (9), p.3808-3820

1989

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Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

Molecular and cellular biology, 1986-11, Vol.6 (11), p.4039-4045

1986

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Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr 1 Gene

Molecular and cellular biology, 1986-11, Vol.6 (11), p.4039-4045

1986

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16 - Expression, Amplification, and Transfer of DNA Sequences Associated with Multidrug Resistance

Mechanisms of Drug Resistance in Neoplastic Cells, 1988, p.243-257

1988

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Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies

Genetics in medicine, 2019-03, Vol.21 (3), p.663-675

2019

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External Validation of Clinical Prediction Models in Unilateral Primary Aldosteronism

American journal of hypertension, 2022-04, Vol.35 (4), p.365-373

2022

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Production of inactivated influenza H5N1 vaccines from MDCK cells in serum-free medium

PloS one, 2011-01, Vol.6 (1), p.e14578-e14578

2011

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Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA

A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys

Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

Optimization of triazole-based TGR5 agonists towards orally available agents

Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

Pharmacological Characterization of Human, Monkey and Rat MT1 and MT2 Receptors

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl -4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6- y l]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling

Galanin function in the central nervous system

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

DNA Polymorphism of the C4 Genes: A New Marker for Analysis of the Major Histocompatibility Complex

Isolation of Human mdr DNA Sequences Amplified in Multidrug-Resistant KB Carcinoma Cells

Evidence for hybrid rodent and human insulin receptors in transfected cells

Substrates and signalling complexes: The tortured path to insulin action

Structure and Expression of the Human MDR (P-Glycoprotein) Gene Family

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr 1 Gene

16 - Expression, Amplification, and Transfer of DNA Sequences Associated with Multidrug Resistance

Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies

External Validation of Clinical Prediction Models in Unilateral Primary Aldosteronism

Production of inactivated influenza H5N1 vaccines from MDCK cells in serum-free medium

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