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Small molecule recognition of disease-relevant RNA structures

Chemical Society reviews, 2020-10, Vol.49 (19), p.7167-7199

2020

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Incorporating Chemical Modification Constraints into a Dynamic Programming Algorithm for Prediction of RNA Secondary Structure

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (19), p.7287-7292

2004

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Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

Journal of the American Chemical Society, 2017-03, Vol.139 (9), p.3446-3455

2017

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Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (5), p.2406-2411

2020

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Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

ACS chemical biology, 2016-06, Vol.11 (6), p.1720-1728

2016

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CONSUMER PERCEPTION OF FAT REDUCTION IN CHEESE

Journal of sensory studies, 2009-12, Vol.24 (6), p.902-921

2009

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A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

Journal of the American Chemical Society, 2019-02, Vol.141 (7), p.2960-2974

2019

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Design of small molecules targeting RNA structure from sequence

Chemical Society reviews, 2020-10, Vol.49 (2), p.7252-727

2020

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DNA‐Encoded Libraries and Their Application to RNA

Israel journal of chemistry, 2023-10, Vol.63 (10-11), p.n/a

2023

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The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

PloS one, 2019-07, Vol.14 (7), p.e0219210-e0219210

2019

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RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

PloS one, 2019-06, Vol.14 (6), p.e0213758-e0213758

2019

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Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Nature communications, 2013-06, Vol.4 (1), p.2044-2044, Article 2044

2013

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Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

ACS central science, 2017-03, Vol.3 (3), p.205-216

2017

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Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners

Journal of the American Chemical Society, 2008-08, Vol.130 (33), p.11185-11194

2008

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Targeting RNA structures with small molecules

Nature reviews. Drug discovery, 2022-10, Vol.21 (10), p.736-762

2022

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The Hairpin Form of r(G 4 C 2 ) exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

Cell chemical biology, 2019-02, Vol.26 (2), p.179-190.e12

2019

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A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence

Chem, 2018-10, Vol.4 (10), p.2384-2404

2018

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A Small Molecule Microarray Platform To Select RNA Internal Loop−Ligand Interactions

ACS chemical biology, 2007-11, Vol.2 (11), p.745-754

2007

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How We Think about Targeting RNA with Small Molecules

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.8880-8900

2020

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Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands

Journal of the American Chemical Society, 2020-04, Vol.142 (15), p.6970-6982

2020

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Oligonucleotide Directed Misfolding of RNA Inhibits Candida albicans Group I Intron Splicing

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11091-11096

2002

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Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.123-140

2016

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Heterobifunctional small molecules to modulate RNA function

Trends in pharmacological sciences (Regular ed.), 2024-05, Vol.45 (5), p.449-463

2024

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Using Modularly Assembled Ligands To Bind RNA Internal Loops Separated by Different Distances

Chembiochem : a European journal of chemical biology, 2011-09, Vol.12 (14), p.2143-2146

2011

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Drugging the RNA World

Cold Spring Harbor perspectives in biology, 2018-11, Vol.10 (11), p.a034769

2018

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Small molecule recognition of disease-relevant RNA structures

Incorporating Chemical Modification Constraints into a Dynamic Programming Algorithm for Prediction of RNA Secondary Structure

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

CONSUMER PERCEPTION OF FAT REDUCTION IN CHEESE

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

Design of small molecules targeting RNA structure from sequence

DNA‐Encoded Libraries and Their Application to RNA

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners

Targeting RNA structures with small molecules

The Hairpin Form of r(G 4 C 2 ) exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence

A Small Molecule Microarray Platform To Select RNA Internal Loop−Ligand Interactions

How We Think about Targeting RNA with Small Molecules

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands

Oligonucleotide Directed Misfolding of RNA Inhibits Candida albicans Group I Intron Splicing

Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells

Heterobifunctional small molecules to modulate RNA function

Using Modularly Assembled Ligands To Bind RNA Internal Loops Separated by Different Distances

Drugging the RNA World

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