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Successful Drug Discovery, Volume 5

1, 2021

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Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

Cell reports (Cambridge), 2016-08, Vol.16 (5), p.1273-1286

2016

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Successful Drug Discovery, Volume 4

1, 2019

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Successful drug discovery

2021

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Successful drug discovery

2018

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Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 2. Pharma’s Challenges and Their Commitment to Innovation

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5525-5553

2014

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Successful drug discovery

2019

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The Resurrection of Phenotypic Drug Discovery

ACS medicinal chemistry letters, 2020-10, Vol.11 (10), p.1820-1828

2020

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Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol

Brain research bulletin, 2024-06, Vol.211, p.110935-110935, Article 110935

2024

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N-Methyl-d-Aspartate Antagonists and Neuropathic Pain: The Search for Relief

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2557-2562

2007

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Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

Cancer research (Chicago, Ill.), 2016-03, Vol.76 (6), p.1494-1505

2016

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“I’ll Be Back”: The Resurrection of Dezocine

ACS medicinal chemistry letters, 2021-06, Vol.12 (6), p.961-968

2021

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A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice

Neuropharmacology, 2023-07, Vol.232, p.109515-109515, Article 109515

2023

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Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

mBio, 2014-02, Vol.5 (1), p.e00765

2014

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Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials”

Journal of medicinal chemistry, 2024-07, Vol.67 (14), p.12459-12459

2024

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Non-NAD-like PARP-1 inhibitors in prostate cancer treatment

Biochemical pharmacology, 2019-09, Vol.167, p.149-162

2019

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Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3467-3503

2024

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Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 1. Criticisms Faced by the Pharmaceutical Industry

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5659-5672

2013

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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Blood, 2013-08, Vol.122 (7), p.1293-1304

2013

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Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

PloS one, 2016-01, Vol.11 (1), p.e0147230-e0147230

2016

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Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

Nature communications, 2024-04, Vol.15 (1), p.2862-2862, Article 2862

2024

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Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms

Saudi pharmaceutical journal, 2024-09, Vol.32 (9), p.102148, Article 102148

2024

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Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

Journal of the American Chemical Society, 2016-03, Vol.138 (9), p.3136-3144

2016

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Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents

Bioorganic & medicinal chemistry, 2021-07, Vol.42, p.116251-116251, Article 116251

2021

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Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6), p.1127-1131

2018

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Successful Drug Discovery, Volume 5

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

Successful Drug Discovery, Volume 4

Successful drug discovery

Successful drug discovery

Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 2. Pharma’s Challenges and Their Commitment to Innovation

Successful drug discovery

The Resurrection of Phenotypic Drug Discovery

Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol

N-Methyl-d-Aspartate Antagonists and Neuropathic Pain: The Search for Relief

Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

“I’ll Be Back”: The Resurrection of Dezocine

A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice

Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials”

Non-NAD-like PARP-1 inhibitors in prostate cancer treatment

Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials

Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 1. Criticisms Faced by the Pharmaceutical Industry

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms

Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents

Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin

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