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Vascular Delivery of rAAVrh74.MCK.GALGT2 to the Gastrocnemius Muscle of the Rhesus Macaque Stimulates the Expression of Dystrophin and Laminin α2 Surrogates

Molecular therapy, 2014-04, Vol.22 (4), p.713-724

2014

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Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation

American journal of physiology. Lung cellular and molecular physiology, 2010-04, Vol.298 (4), p.L600-L606

2010

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Persistent Expression of FLAG-tagged Micro dystrophin in Nonhuman Primates Following Intramuscular and Vascular Delivery

Molecular therapy, 2010-01, Vol.18 (1), p.109-117

2010

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A first-in-human phase I/IIa gene transfer clinical trial for Duchenne muscular dystrophy using rAAVrh74.MCK.GALGT2

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.47-60

2022

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A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy

Journal of translational medicine, 2007-09, Vol.5 (1), p.45-45, Article 45

2007

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Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells

American journal of physiology. Lung cellular and molecular physiology, 2004-07, Vol.287 (1), p.L60-L68

2004

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AAV-mediated gene therapy to the isolated limb in rhesus macaques

Methods in molecular biology (Clifton, N.J.), 2011-01, Vol.709, p.287

2011

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Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Molecular therapy. Methods & clinical development, 2018-03, Vol.8 (C), p.8-20

2018

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Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.233-242

2019

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An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque

Molecular therapy. Methods & clinical development, 2018-09, Vol.10, p.89-104

2018

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Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling

American journal of physiology. Lung cellular and molecular physiology, 2014-08, Vol.307 (4), p.L317-L325

2014

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Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders

Molecular therapy, 2011-11, Vol.19 (11), p.1971-1980

2011

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Gene Delivery for Limb-Girdle Muscular Dystrophy Type 2D by Isolated Limb Infusion

Human gene therapy, 2019-07, Vol.30 (7), p.794

2019

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Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone

Human gene therapy, 2017-06, Vol.28 (6), p.493

2017

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Vascular Delivery of rAAVrh74.MCK.GALGT2 to the Gastrocnemius Muscle of the Rhesus Macaque Stimulates the Expression of Dystrophin and Laminin alpha 2 Surrogates

Molecular therapy, 2014-04, Vol.22 (4), p.713-724

2014

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Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells

American journal of physiology. Lung cellular and molecular physiology, 2017-05, Vol.312 (5), p.L649-L656

2017

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A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia

Acta Paediatrica, 2016-04, Vol.105 (4), p.e170-e175

2016

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Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

Clinical and experimental pharmacology & physiology, 2011-12, Vol.38 (12), p.796-803

2011

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Inhaled Nitric Oxide Prevents 3-Nitrotyrosine Formation in the Lungs of Neonatal Mice Exposed to >95% Oxygen

Lung, 2010-06, Vol.188 (3), p.217-227

2010

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Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells

Clinical and experimental pharmacology & physiology, 2014-07, Vol.41 (7), p.469-474

2014

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Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice

American Journal of Physiology: Cell Physiology, 2009-03, Vol.296 (3), p.C476-C488

2009

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Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

American journal of physiology. Heart and circulatory physiology, 2010-05, Vol.298 (5), p.H1518-H1528

2010

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Lung Development Alterations in Newborn Mice after Recovery from Exposure to Sublethal Hyperoxia

The American journal of pathology, 2014-04, Vol.184 (4), p.1010-1016

2014

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Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine

American journal of physiology. Heart and circulatory physiology, 2013-01, Vol.304 (2), p.H195-H205

2013

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L-Lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs

Pediatric research, 2004-06, Vol.55 (6), p.979-987

2004

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Vascular Delivery of rAAVrh74.MCK.GALGT2 to the Gastrocnemius Muscle of the Rhesus Macaque Stimulates the Expression of Dystrophin and Laminin α2 Surrogates

Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation

Persistent Expression of FLAG-tagged Micro dystrophin in Nonhuman Primates Following Intramuscular and Vascular Delivery

A first-in-human phase I/IIa gene transfer clinical trial for Duchenne muscular dystrophy using rAAVrh74.MCK.GALGT2

A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy

Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells

AAV-mediated gene therapy to the isolated limb in rhesus macaques

Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study

An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque

Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling

Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders

Gene Delivery for Limb-Girdle Muscular Dystrophy Type 2D by Isolated Limb Infusion

Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone

Vascular Delivery of rAAVrh74.MCK.GALGT2 to the Gastrocnemius Muscle of the Rhesus Macaque Stimulates the Expression of Dystrophin and Laminin alpha 2 Surrogates

Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells

A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia

Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

Inhaled Nitric Oxide Prevents 3-Nitrotyrosine Formation in the Lungs of Neonatal Mice Exposed to >95% Oxygen

Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells

Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

Lung Development Alterations in Newborn Mice after Recovery from Exposure to Sublethal Hyperoxia

Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine

L-Lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs

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