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Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors

The Journal of biological chemistry, 2020-08, Vol.295 (33), p.11495-11512

2020

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Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors

Neuropharmacology, 2015-09, Vol.96 (Pt B), p.169-177

2015

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A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor

The Journal of biological chemistry, 2019-05, Vol.294 (19), p.7892-7903

2019

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Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol

Current neuropharmacology, 2016-10, Vol.14 (7), p.772-780

2016

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Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6554-6565

2012

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Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

The Journal of biological chemistry, 2008-08, Vol.283 (32), p.22051-22062

2008

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Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog

The Journal of biological chemistry, 2014-10, Vol.289 (40), p.27456-27468

2014

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Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [3H]Azietomidate, an Open-State Inhibitor

Molecular pharmacology, 2009-05, Vol.75 (5), p.1084-1095

2009

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Identification of a GABAA Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

The Journal of neuroscience, 2006-11, Vol.26 (45), p.11599-11605

2006

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Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses

The Journal of biological chemistry, 2017-06, Vol.292 (24), p.9988-10001

2017

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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α 1 β 3 γ 2 GABA A R Transmembrane Domain

Molecular pharmacology, 2019-06, Vol.95 (6), p.615-628

2019

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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs)

The Journal of biological chemistry, 2016-12, Vol.291 (51), p.26529-26539

2016

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Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

The Journal of biological chemistry, 2010-03, Vol.285 (12), p.8615-8620

2010

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Photoaffinity Labeling the Propofol Binding Site in GLIC

Biochemistry (Easton), 2014-01, Vol.53 (1), p.135-142

2014

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Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1598, p.157

2017

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Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors

European journal of medicinal chemistry, 2019-01, Vol.162 (C), p.810-824

2019

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Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

The Journal of biological chemistry, 2009-05, Vol.284 (18), p.11771-11775

2009

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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain

Molecular pharmacology, 2019-06, Vol.95 (6), p.615-628

2019

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Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands

European journal of medicinal chemistry, 2017-08, Vol.136 (C), p.334-347

2017

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Photoaffinity Labeling of Nicotinic Receptors: Diversity of Drug Binding Sites

Journal of molecular neuroscience, 2014-07, Vol.53 (3), p.480-486

2014

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Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate

Molecular pharmacology, 2014-05, Vol.85 (5), p.735-746

2014

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Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABAA) Receptors

The Journal of biological chemistry, 2013-10, Vol.288 (42), p.30373-30386

2013

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Conformational Changes in the Nicotinic Acetylcholine Receptor during Gating and Desensitization

Biochemistry (Easton), 2010-01, Vol.49 (1), p.156-165

2010

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p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol

Journal of medicinal chemistry, 2011-12, Vol.54 (23), p.8124-8135

2011

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Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β− Interface

The Journal of biological chemistry, 2015-09, Vol.290 (38), p.23432-23446

2015

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Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors

Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors

A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol

Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog

Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [3H]Azietomidate, an Open-State Inhibitor

Identification of a GABAA Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α 1 β 3 γ 2 GABA A R Transmembrane Domain

General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs)

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

Photoaffinity Labeling the Propofol Binding Site in GLIC

Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands

Photoaffinity Labeling of Nicotinic Receptors: Diversity of Drug Binding Sites

Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate

Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABAA) Receptors

Conformational Changes in the Nicotinic Acetylcholine Receptor during Gating and Desensitization

p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β− Interface

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