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Targeting the mTOR signaling network in cancer

Trends in molecular medicine, 2007-10, Vol.13 (10), p.433-442

2007

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Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase

The Journal of biological chemistry, 2005-07, Vol.280 (27), p.25485-25490

2005

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5879-5955

2020

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The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

PloS one, 2015-07, Vol.10 (7), p.e0131716-e0131716

2015

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Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

Cell reports (Cambridge), 2021-06, Vol.35 (13), p.109321-109321, Article 109321

2021

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Control of mTORC1 signaling by the Opitz syndrome protein MID1

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (21), p.8680-8685

2011

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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

ACS medicinal chemistry letters, 2014-02, Vol.5 (2), p.205-209

2014

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Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway

Molecular cell, 2005-09, Vol.19 (5), p.607-618

2005

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Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

Frontiers in oncology, 2021-11, Vol.11, p.766298-766298

2021

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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (7), p.1576-1583

2017

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The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2505-2514

2007

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Discovery of A‑893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.695-700

2015

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Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8), p.3287-3298

2010

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mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation

JCI insight, 2021-06, Vol.6 (11)

2021

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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

Bioorganic & medicinal chemistry, 2004-09, Vol.12 (17), p.4749-4759

2004

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

The Journal of biological chemistry, 2011-12, Vol.286 (49), p.42626-42634

2011

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Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A

Molecular cancer therapeutics, 2021-01, Vol.20 (1), p.26-36

2021

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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Molecular and Cellular Biology, 2002-10, Vol.22 (20), p.7004-7014

2002

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The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

Molecular cell, 2008-12, Vol.32 (6), p.862-869

2008

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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

EMBO reports, 2009-08, Vol.10 (8), p.866-872

2009

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Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

Molecular cancer therapeutics, 2017-07, Vol.16 (7), p.1236-1245

2017

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Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8451-8460

2003

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Targeting the mTOR signaling network in cancer

Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

Control of mTORC1 signaling by the Opitz syndrome protein MID1

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway

Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Discovery of A‑893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells

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