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Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.625-633

2008

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Identification of Residues Important for Agonist Recognition and Activation in GPR40

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29248-29255

2007

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Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2981-2989

2007

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An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay

Platelets (Edinburgh), 2022-10, Vol.33 (7), p.979-986

2022

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Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

The Journal of biological chemistry, 2009-02, Vol.284 (6), p.3529-3536

2009

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Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds

Current chemical genomics and translational medicine, 2014-02, Vol.8 (1), p.16-26

2014

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Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor

Biochemical pharmacology, 2007-07, Vol.74 (2), p.236-255

2007

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Abstract 1869: Novel TNFR2 antibodies to overcome T cell exhaustion and suppressive tumor microenvironment

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1869-1869

2021

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Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens

British journal of pharmacology, 1996-07, Vol.118 (6), p.1523-1529

1996

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Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells

European journal of pharmacology, 2001-06, Vol.421 (1), p.11-22

2001

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Effects of N-Ethylmaleimide on Conformational Equilibria in Purified Cardiac Muscarinic Receptors

The Journal of biological chemistry, 2002-09, Vol.277 (39), p.36188-36203

2002

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Apparent capacity of cardiac muscarinic receptors for different radiolabeled antagonists

Biochemical pharmacology, 2001-10, Vol.62 (7), p.829-851

2001

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GPCR profiling: from hits to leads and from genotype to phenotype

Drug discovery today. Technologies, 2015-11, Vol.18, p.30-37

2015

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Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

ACS medicinal chemistry letters, 2018-01, Vol.9 (1), p.17-22

2018

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Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors

The Journal of pharmacology and experimental therapeutics, 2016-02, Vol.356 (2), p.293-304

2016

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Cholesterol as a determinant of cooperativity in the M 2 muscarinic cholinergic receptor

Biochemical pharmacology, 2007-07, Vol.74 (2), p.236-255

2007

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Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor ActivationS

The Journal of biological chemistry, 2009-02, Vol.284 (6), p.3529-3536

2009

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Discovery of novel agonists and antagonists of the free fatty acid receptor one (FFAR1) using virtual screening

Journal of medicinal chemistry, 2008-01, Vol.51 (3), p.625-633

2008

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Transactivation of PDGFR[beta] by dopamine D4 receptor does not require PDGFR[beta] dimerization

Molecular brain, 2010-07, Vol.3, p.22

2010

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A bi-directional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2981-2989

2007

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Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization

Molecular brain, 2010-07, Vol.3 (1), p.22-22, Article 22

2010

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Cooperativity and Oligomeric Status of Cardiac Muscarinic Cholinergic Receptors

Biochemistry (Easton), 2002-04, Vol.41 (17), p.5588-5604

2002

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Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization

Molecular brain, 2010-07, Vol.3, p.22

2010

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Apparent capacity of cardiac muscarinic receptors for different radiolabeled antagonists 6 6Abbreviations: ABT, 3-(2′-aminobenzhydryloxy)tropane; ECL, enhanced chemiluminescence; NMS, N-methylscopolamine; PMSF, phenylmethylsulfonyl fluoride; and QNB, l-quinuclidinylbenzilate

Biochemical pharmacology, 2001-10, Vol.62 (7), p.829-851

2001

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Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Identification of Residues Important for Agonist Recognition and Activation in GPR40

Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition

An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds

Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4

Abstract 1869: Novel TNFR2 antibodies to overcome T cell exhaustion and suppressive tumor microenvironment

Potentiation of purinergic transmission by angiotensin in prostatic rat vas deferens

Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells

Effects of N-Ethylmaleimide on Conformational Equilibria in Purified Cardiac Muscarinic Receptors

Apparent capacity of cardiac muscarinic receptors for different radiolabeled antagonists

GPCR profiling: from hits to leads and from genotype to phenotype

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors

Cholesterol as a determinant of cooperativity in the M 2 muscarinic cholinergic receptor

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor ActivationS

Discovery of novel agonists and antagonists of the free fatty acid receptor one (FFAR1) using virtual screening

Transactivation of PDGFR[beta] by dopamine D4 receptor does not require PDGFR[beta] dimerization

A bi-directional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization

Cooperativity and Oligomeric Status of Cardiac Muscarinic Cholinergic Receptors

Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization

Apparent capacity of cardiac muscarinic receptors for different radiolabeled antagonists 6 6Abbreviations: ABT, 3-(2′-aminobenzhydryloxy)tropane; ECL, enhanced chemiluminescence; NMS, N-methylscopolamine; PMSF, phenylmethylsulfonyl fluoride; and QNB, l-quinuclidinylbenzilate

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