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Improving user performance

IEEE journal on selected areas in communications, 1991-05, Vol.9 (4), p.506-517

1991

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Synthesis of N,N,N'-trisubstituted N"-cyanoguanidines and N-aryl-N'-(triorganostannyl)-N'N"-dicyanoguanidines

Journal of chemical and engineering data, 1981-01, Vol.26 (1), p.105-106

1981

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A randomized phase III study evaluating the efficacy of single-dose NEPA, a fixed antiemetic combination of netupitant and palonosetron, versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC)

Annals of oncology, 2018-02, Vol.29 (2), p.452-458

2018

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A Strategy for the Nonlinear Control of Affine Systems using Multiple Neural Networks

1993 American Control Conference, 1993, p.1470-1474

1993

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From fragment to clinical candidate—a historical perspective

Drug discovery today, 2009-07, Vol.14 (13), p.668-675

2009

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Recent Developments in Fragment-Based Drug Discovery

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3661-3680

2008

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ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Molecular cancer therapeutics, 2018-07, Vol.17 (7), p.1381-1391

2018

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Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.726-741

2007

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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Nature chemical biology, 2012-11, Vol.8 (11), p.920-925

2012

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Modeling Water Molecules in Protein−Ligand Docking Using GOLD

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6504-6515

2005

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28 (PB016): Identification of biomarkers predictive of response to ASTX295, a nextgeneration MDM2 antagonist, in solid tumors carrying wild-type p53

European journal of cancer (1990), 2024-10, Vol.211, p.114556, Article 114556

2024

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73 (PB061): Targeting the catalytic HAT domain of CBP/p300 for the treatment of hormone-dependent breast and prostate cancers

European journal of cancer (1990), 2024-10, Vol.211, p.114600, Article 114600

2024

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42 (PB030): A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species

European journal of cancer (1990), 2024-10, Vol.211, p.114570, Article 114570

2024

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Low SKP2 expression is predictive of sensitivity to an MDM2 antagonist in p53 wild-type AML

European journal of cancer (1990), 2022-10, Vol.174, p.S83-S84

2022

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289 (PB277): Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivo

European journal of cancer (1990), 2024-10, Vol.211, p.114804, Article 114804

2024

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.4071-4088

2021

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Accelerated Chemical Reaction Optimization Using Multi-Task Learning

ACS central science, 2023-05, Vol.9 (5), p.957-968

2023

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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4463-4476

2003

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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6574-6588

2015

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Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1124-1132

2007

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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)

Journal of medicinal chemistry, 2017-06, Vol.60 (11), p.4611-4625

2017

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Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Journal of medicinal chemistry, 2010-08, Vol.53 (16), p.5942-5955

2010

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SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

Cell death & disease, 2013-07, Vol.4 (7), p.e733-e733

2013

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Improving user performance

Synthesis of N,N,N'-trisubstituted N"-cyanoguanidines and N-aryl-N'-(triorganostannyl)-N'N"-dicyanoguanidines

A randomized phase III study evaluating the efficacy of single-dose NEPA, a fixed antiemetic combination of netupitant and palonosetron, versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC)

A Strategy for the Nonlinear Control of Affine Systems using Multiple Neural Networks

From fragment to clinical candidate—a historical perspective

Recent Developments in Fragment-Based Drug Discovery

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Modeling Water Molecules in Protein−Ligand Docking Using GOLD

28 (PB016): Identification of biomarkers predictive of response to ASTX295, a nextgeneration MDM2 antagonist, in solid tumors carrying wild-type p53

73 (PB061): Targeting the catalytic HAT domain of CBP/p300 for the treatment of hormone-dependent breast and prostate cancers

42 (PB030): A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species

Low SKP2 expression is predictive of sensitivity to an MDM2 antagonist in p53 wild-type AML

289 (PB277): Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivo

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Accelerated Chemical Reaction Optimization Using Multi-Task Learning

Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

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