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SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

Cell death & disease, 2013-07, Vol.4 (7), p.e733-e733

2013

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380 Induction of apoptosis with a novel dual cIAP1/XIAP antagonist in models of melanoma

European journal of cancer (1990), 2014-11, Vol.50, p.122-122

2014

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85 Characterization of a Potent XIAP and CIAP1 Dual Antagonist in Models of Melanoma and Leukemia

European journal of cancer (1990), 2012-11, Vol.48, p.27-27

2012

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871 FRAGMENT BASED DISCOVERY AND GENOTYPIC PROFILING OF A SERIES OF DIRECT ACTING ANTIVIRAL AGENTS WITH A NOVEL MODE OF ACTION

Journal of hepatology, 2012-04, Vol.56, p.S339-S339

2012

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28 (PB016): Identification of biomarkers predictive of response to ASTX295, a nextgeneration MDM2 antagonist, in solid tumors carrying wild-type p53

European journal of cancer (1990), 2024-10, Vol.211, p.114556, Article 114556

2024

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73 (PB061): Targeting the catalytic HAT domain of CBP/p300 for the treatment of hormone-dependent breast and prostate cancers

European journal of cancer (1990), 2024-10, Vol.211, p.114600, Article 114600

2024

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289 (PB277): Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivo

European journal of cancer (1990), 2024-10, Vol.211, p.114804, Article 114804

2024

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42 (PB030): A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species

European journal of cancer (1990), 2024-10, Vol.211, p.114570, Article 114570

2024

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Low SKP2 expression is predictive of sensitivity to an MDM2 antagonist in p53 wild-type AML

European journal of cancer (1990), 2022-10, Vol.174, p.S83-S84

2022

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Modeling Water Molecules in Protein−Ligand Docking Using GOLD

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6504-6515

2005

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Identification of potent small molecule allosteric inhibitors of SHP2

European journal of cancer (1990), 2020-10, Vol.138, p.S44-S44

2020

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Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1124-1132

2007

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Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors

Journal of medicinal chemistry, 2006-02, Vol.49 (4), p.1346-1355

2006

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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4463-4476

2003

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592 Characterisation of novel, small molecule antagonists of XIAP, cIAP1 and cIAP2 generated by fragment based drug discovery (FBDD)

European journal of cancer supplements, 2010, Vol.8 (7), p.186-186

2010

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Detection of Localized Water Clusters in a Charged Peptidyl Resin

Journal of the American Chemical Society, 2001-12, Vol.123 (48), p.12103-12104

2001

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High resolution magic angle spinning NMR in combinatorial chemistry

Combinatorial chemistry & high throughput screening, 2001-06, Vol.4 (4), p.333-351

2001

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573 POSTER Identification of potent, selective JAK2 inhibitors using a fragment-based screening approach

European journal of cancer supplements, 2008, Vol.6 (12), p.180-180

2008

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PS988 CHARACTERIZATION OF A NOVEL, POTENT SMALL MOLECULE MDM2 ANTAGONIST WHICH ACTIVATES WILD‐TYPE P53 AND INDUCES APOPTOSIS IN AML

HemaSphere, 2019-06, Vol.3 (S1), p.443-444

2019

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Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition

Nucleic acids research, 2003-03, Vol.31 (5), p.1514-1524

2003

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Quantitative Determination of Intermolecular Interactions with Fluorinated Aromatic Rings

Chemistry : a European journal, 2001-08, Vol.7 (16), p.3494-3503

2001

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An Evaluation of Force-Field Treatments of Aromatic Interactions

Chemistry : a European journal, 2002-07, Vol.8 (13), p.2860-2867

2002

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Singly Bridged Calix[8]crowns

Journal of organic chemistry, 2000-08, Vol.65 (17), p.5143-5151

2000

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Application of Fragment Screening by X-ray Crystallography to beta -Secretaset

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1116-1123

2007

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Rotor Synchronization of Radiofrequency and Gradient Pulses in High-Resolution Magic Angle Spinning NMR

Journal of magnetic resonance (1997), 2001-09, Vol.152 (1), p.95-102

2001

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SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

380 Induction of apoptosis with a novel dual cIAP1/XIAP antagonist in models of melanoma

85 Characterization of a Potent XIAP and CIAP1 Dual Antagonist in Models of Melanoma and Leukemia

871 FRAGMENT BASED DISCOVERY AND GENOTYPIC PROFILING OF A SERIES OF DIRECT ACTING ANTIVIRAL AGENTS WITH A NOVEL MODE OF ACTION

28 (PB016): Identification of biomarkers predictive of response to ASTX295, a nextgeneration MDM2 antagonist, in solid tumors carrying wild-type p53

73 (PB061): Targeting the catalytic HAT domain of CBP/p300 for the treatment of hormone-dependent breast and prostate cancers

289 (PB277): Pulsatile induction of the p53 pathway by MDM2 antagonist ASTX295 shows an enhanced therapeutic index in vivo

42 (PB030): A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species

Low SKP2 expression is predictive of sensitivity to an MDM2 antagonist in p53 wild-type AML

Modeling Water Molecules in Protein−Ligand Docking Using GOLD

Identification of potent small molecule allosteric inhibitors of SHP2

Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors

Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

592 Characterisation of novel, small molecule antagonists of XIAP, cIAP1 and cIAP2 generated by fragment based drug discovery (FBDD)

Detection of Localized Water Clusters in a Charged Peptidyl Resin

High resolution magic angle spinning NMR in combinatorial chemistry

573 POSTER Identification of potent, selective JAK2 inhibitors using a fragment-based screening approach

PS988 CHARACTERIZATION OF A NOVEL, POTENT SMALL MOLECULE MDM2 ANTAGONIST WHICH ACTIVATES WILD‐TYPE P53 AND INDUCES APOPTOSIS IN AML

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition

Quantitative Determination of Intermolecular Interactions with Fluorinated Aromatic Rings

An Evaluation of Force-Field Treatments of Aromatic Interactions

Singly Bridged Calix[8]crowns

Application of Fragment Screening by X-ray Crystallography to beta -Secretaset

Rotor Synchronization of Radiofrequency and Gradient Pulses in High-Resolution Magic Angle Spinning NMR

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