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Regulation of small GTPases by GEFs, GAPs, and GDIs

Physiological reviews, 2013-01, Vol.93 (1), p.269-309

2013

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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Nature reviews. Cancer, 2010-12, Vol.10 (12), p.842

2010

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Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (43), p.11416-11421

2017

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A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

Nature communications, 2019-03, Vol.10 (1), p.1142-1142, Article 1142

2019

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Small GTPase signaling hubs at the surface of cellular membranes in physiology and disease

FEBS letters, 2023-03, Vol.597 (6), p.717-720

Cherfils, Jacqueline

2023

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Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Nature, 2003-12, Vol.426 (6966), p.525-530

2003

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Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

Trends in pharmacological sciences (Regular ed.), 2005-03, Vol.26 (3), p.138-145

2005

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Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

Current opinion in structural biology, 2014-12, Vol.29, p.67-76

Cherfils, Jacqueline

2014

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Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Nature communications, 2023-07, Vol.14 (1), p.4157-4157, Article 4157

2023

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Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Science (American Association for the Advancement of Science), 2014-04, Vol.344 (6180), p.208-211

2014

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MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

Nature communications, 2019-11, Vol.10 (1), p.5300-12, Article 5300

2019

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On the explicit use of experimental images in high resolution cryo-EM reﬁnement [version 1; peer review: 2 approved]

F1000 research, 2019, Vol.8, p.665

2019

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Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex

Molecular cell, 2017-12, Vol.68 (5), p.823-824

Cherfils, Jacqueline

2017

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Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Scientific reports, 2017-10, Vol.7 (1), p.14409-13, Article 14409

2017

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Structure (London), 2019-12, Vol.27 (12), p.1782-1797.e7

2019

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Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Nature communications, 2015-02, Vol.6 (1), p.6218, Article 6218

2015

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Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

The Journal of cell biology, 2006-02, Vol.172 (5), p.645-650

2006

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Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex

International journal of molecular sciences, 2021-04, Vol.22 (8), p.4115

2021

Volltextzugriff (PDF)

On the explicit use of experimental images in high resolution cryo-EM reﬁnement [version 2; peer review: 2 approved]

F1000 research, 2019, Vol.8, p.665-665

2019

Volltextzugriff (PDF)

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12378-12383

2014

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PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration

Neurobiology of disease, 2020-03, Vol.136, p.104709-104709, Article 104709

2020

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RhoGDIs Revisited: Novel Roles in Rho Regulation

Traffic (Copenhagen, Denmark), 2005-11, Vol.6 (11), p.957-966

2005

Volltextzugriff (PDF)

Allosteric Regulation of Small GTPases on Membranes

Biophysical journal, 2018-02, Vol.114 (3), p.185a-186a

Cherfils, Jacqueline

2018

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Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2

PLoS biology, 2013-09, Vol.11 (9), p.e1001652-e1001652

2013

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Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction

European journal of medicinal chemistry reports, 2022-12, Vol.6, p.100090, Article 100090

2022

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Regulation of small GTPases by GEFs, GAPs, and GDIs

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

Small GTPase signaling hubs at the surface of cellular membranes in physiology and disease

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

On the explicit use of experimental images in high resolution cryo-EM reﬁnement [version 1; peer review: 2 approved]

Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex

On the explicit use of experimental images in high resolution cryo-EM reﬁnement [version 2; peer review: 2 approved]

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration

RhoGDIs Revisited: Novel Roles in Rho Regulation

Allosteric Regulation of Small GTPases on Membranes

Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2

Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction

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