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Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer

Journal of the American Chemical Society, 2019-06, Vol.141 (22), p.8752-8757

2019

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Ligand-Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts

Angewandte Chemie (International ed.), 2016-01, Vol.55 (2), p.785-789

International ed. in English, 2016

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Ligand-accelerated non-directed C-H functionalization of arenes

Nature (London), 2017-11, Vol.551 (7681), p.489-493

2017

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Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5928-5933

2007

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Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis

Journal of the American Chemical Society, 2022-09, Vol.144 (38), p.17709-17720

2022

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Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278

Toxicology and applied pharmacology, 2022-03, Vol.438, p.115885-115885, Article 115885

2022

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Alkene Difunctionalization Directed by Free Amines: Diamine Synthesis via Nickel-Catalyzed 1,2-Carboamination

ACS catalysis, 2022-04, Vol.12 (7), p.3890-3896

2022

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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4291-4317

2022

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Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities

Toxicologic pathology, 2015-08, Vol.43 (6), p.825-837

2015

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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (6), p.1196-1205

2015

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Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Journal of medicinal chemistry, 2010-04, Vol.53 (7), p.2854-2864

2010

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Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1939-1944

2008

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PPARs as targets for metabolic and cardiovascular diseases

Mini reviews in medicinal chemistry, 2005-08, Vol.5 (8), p.741

2005

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Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1451-1456

2009

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A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPAR α/ γ activator

Analytical biochemistry, 2007-04, Vol.363 (2), p.263-274

2007

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Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2933-2937

2010

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Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2312-2316

2007

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Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor [alpha] Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Journal of medicinal chemistry, 2010-04, Vol.53 ((7) ; 04, 2010)

2010

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Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism

Chirality (New York, N.Y.), 2006, Vol.18 (9), p.746-753

2006

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A synthetic approach to secologanin: synthesis of a protected form of the secoxyloganin aglucone

Tetrahedron letters, 1988, Vol.29 (29), p.3511-3512

1988

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A general synthesis of dioxolenone prodrug moieties

Tetrahedron letters, 2002-02, Vol.43 (7), p.1161-1164

2002

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A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

Tetrahedron letters, 1997-05, Vol.38 (18), p.3175-3178

1997

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Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer

Ligand-Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts

Ligand-accelerated non-directed C-H functionalization of arenes

Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues

Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis

Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278

Alkene Difunctionalization Directed by Free Amines: Diamine Synthesis via Nickel-Catalyzed 1,2-Carboamination

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)

Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities

Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists

Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

PPARs as targets for metabolic and cardiovascular diseases

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists

A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPAR α/ γ activator

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor [alpha] Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism

A synthetic approach to secologanin: synthesis of a protected form of the secoxyloganin aglucone

A general synthesis of dioxolenone prodrug moieties

A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

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