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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14522-14529

2020

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Enantioselective Organocatalytic Amine Conjugate Addition

Journal of the American Chemical Society, 2006-07, Vol.128 (29), p.9328-9329

2006

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TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase

Anti-cancer drugs, 2023-11

2023

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Catalytic Asymmetric Synthesis of Hydroxy Enol Ethers: Approach to a Two-Carbon Homologation of Aldehydes

Organic letters, 2005-04, Vol.7 (9), p.1729-1732

2005

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.1747-1757

2024

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TACH101, a first-in-class pan-inhibitor of KDM4 for treatment of gastrointestinal cancers

Journal of clinical oncology, 2022-02, Vol.40 (4_suppl), p.132-132

2022

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (1), p.103-106

2019

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models

ACS medicinal chemistry letters, 2017-08, Vol.8 (8), p.869-874

2017

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A General, Highly Enantioselective Method for the Synthesis of d and l α-Amino Acids and Allylic Amines

Journal of the American Chemical Society, 2002-10, Vol.124 (41), p.12225-12231

2002

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One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols

Journal of the American Chemical Society, 2009-06, Vol.131 (24), p.8434-8445

2009

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A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols

Journal of the American Chemical Society, 2004-03, Vol.126 (12), p.3702-3703

2004

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Substrate Dependence of Nonlinear Effects: Mechanistic Probe and Practical Applications

Journal of the American Chemical Society, 2001-06, Vol.123 (22), p.5378-5379

2001

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Abstract 2128: TACH101, a first-in-class pan inhibitor of KDM4 histone lysine demethylases

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.2128-2128

2021

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Inhibition of histone lysine demethylases with TACH101, a first-in-class pan-inhibitor of KDM4

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.3105-3105

2021

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Pharmacologic characterization of TACH101, a first-in-class KDM4 inhibitor for development as a cancer therapeutic

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.e15067-e15067

2021

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Inhibition of cancer stem cells with TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e15105-e15105

2022

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Abstract P086: Identification of pharmacodynamic and sensitivity biomarkers for TACH101, a pan-inhibitor of KDM4 histone lysine demethylase

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P086-P086

2021

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Abstract 3720: TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase for the treatment of diffuse large B-cell lymphoma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3720-3720

2022

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High-performance oxygen reduction and evolution carbon catalysis： From mechanistic studies to device integration

Nano research, 2017-04, Vol.10 (4), p.1163-1177

2017

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Catalytic asymmetric organozinc reactions: Mechanisms and synthetic utilities

Chen, Young K

2004

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CONSISTENCY OF VISION, LENS ROTATION, AND COMFORT OF CIBA FOCUS TORIC MONTHLY REPLACEMENT SOFT CONTACT LENSES: Poster # 60 (CL-130)

Optometry and vision science, 1994-12, Vol.71 (Supplement), p.54

1994

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A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols

ChemInform, 2004-07, Vol.35 (30), p.no-no

2004

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Enantioselective Organocatalytic Amine Conjugate Addition

ChemInform, 2006-12, Vol.37 (49), p.no-no

2006

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ChemInform Abstract: One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols

ChemInform, 2009-11, Vol.40 (45), p.no-no

2009

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Catalytic Asymmetric Synthesis of Hydroxy Enol Ethers: Approach to a Two-Carbon Homologation of Aldehydes

ChemInform, 2005-09, Vol.36 (38), p.no-no

2005

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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)

Enantioselective Organocatalytic Amine Conjugate Addition

TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase

Catalytic Asymmetric Synthesis of Hydroxy Enol Ethers: Approach to a Two-Carbon Homologation of Aldehydes

The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition

TACH101, a first-in-class pan-inhibitor of KDM4 for treatment of gastrointestinal cancers

Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models

A General, Highly Enantioselective Method for the Synthesis of d and l α-Amino Acids and Allylic Amines

One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols

A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols

Substrate Dependence of Nonlinear Effects: Mechanistic Probe and Practical Applications

Abstract 2128: TACH101, a first-in-class pan inhibitor of KDM4 histone lysine demethylases

Inhibition of histone lysine demethylases with TACH101, a first-in-class pan-inhibitor of KDM4

Pharmacologic characterization of TACH101, a first-in-class KDM4 inhibitor for development as a cancer therapeutic

Inhibition of cancer stem cells with TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase

Abstract P086: Identification of pharmacodynamic and sensitivity biomarkers for TACH101, a pan-inhibitor of KDM4 histone lysine demethylase

Abstract 3720: TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase for the treatment of diffuse large B-cell lymphoma

High-performance oxygen reduction and evolution carbon catalysis： From mechanistic studies to device integration

Catalytic asymmetric organozinc reactions: Mechanisms and synthetic utilities

CONSISTENCY OF VISION, LENS ROTATION, AND COMFORT OF CIBA FOCUS TORIC MONTHLY REPLACEMENT SOFT CONTACT LENSES: Poster # 60 (CL-130)

A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols

Enantioselective Organocatalytic Amine Conjugate Addition

ChemInform Abstract: One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols

Catalytic Asymmetric Synthesis of Hydroxy Enol Ethers: Approach to a Two-Carbon Homologation of Aldehydes

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