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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the α2δ subunit of voltage gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1295-1298

2004

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]-pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2031-2034

2004

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Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5485-5488

2004

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Expedited SAR study of high-affinity ligands to the α2δ subunit of voltage-gated calcium channels : Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.746-749

2006

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Thermal cycloreversion of 2,2-dimethyl-6 (.omega.-hydroxyalkyl)-4H-1,3-dioxin-4-ones: mono-, di-, and trimeric macrocyclic .beta.-keto lactones by intramolecular trapping of (.omega.-hydroxy)acylketenes

Journal of organic chemistry, 1993-08, Vol.58 (18), p.5011-5014

1993

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Expedited SAR study of high-affinity ligands to the α 2δ subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.746-749

2006

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Mass Spectrometric Analyses of β-Ketolactone Oligomers, Macrocyclic or Catenane Structures?

Analytical chemistry (Washington), 1996-01, Vol.68 (1), p.38-45

1996

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Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin Activation/Capture Approach/REACAP Technology

Tetrahedron letters, 1998-09, Vol.39 (38), p.6781-6784

1998

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Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin Activation/Capture Approach/REACAP Technology

Tetrahedron letters, 1999-04, Vol.40 (18), p.3491-3494

1999

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Solid Phase Synthesis of 1,2-Disubstituted Alkenes: A Novel Alkynyldihydropyridine to Alkenylpyridine Isomerization

Synlett, 2003-12, Vol.2003 (15), p.2404-2406

2003

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Resin activation capture technology: Libraries from stabilized acyl-pyridinium on solid support

Biotechnology and bioengineering, 2000-12, Vol.71 (1), p.78-84

2000

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Expedited SAR study of high-affinity ligands to the alpha(2)delta subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.746-749

2006

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Synthesis of dihydropyridone scaffolds on solid support: Resin activation/capture approach/REACAP technology

Tetrahedron letters, 1998-01, Vol.39 (3), p.217-220

1998

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"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis

Journal of the American Chemical Society, 1994-03, Vol.116 (6), p.2661-2662

1994

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Solid phase synthesis of 2,4-disubstituted pyridine and tetrahydropyridine derivatives: Resin activation/capture approach/REACAP technology

Tetrahedron letters, 1998-05, Vol.39 (21), p.3401-3404

1998

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Resin activation capture technology : Libraries from stabilized acyl-pyridinium on solid support: Special Issue on Polymer Supports for Streamlined Organic Synthesis

Biotechnology and bioengineering, 2000, Vol.71 (1), p.78-84

2000

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2031-2034

2004

Volltextzugriff (PDF)

Resin activation capture technology: Libraries from stabilized acyl-pyridinium on solid support

Biotechnology and bioengineering, 2000, Vol.71 (1), p.78-84

2000

Volltextzugriff (PDF)

Synthesis and biological evaluation of 6-aryl-6 H -pyrrolo[3,4- d ]pyridazine derivatives as high-affinity ligands of the α 2 δ subunit of voltage-gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2031-2034

2004

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Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

Journal of organic chemistry, 1994-10, Vol.59 (20), p.5862-5864

1994

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1295-1298

2004

Volltextzugriff (PDF)

Synthesis and biological evaluation of 6-aryl-6 H -pyrrolo[3,4- d ]pyridazine derivatives: high-affinity ligands to the α 2 δ subunit of voltage gated calcium channels

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1295-1298

2004

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The solid-phase combinatorial synthesis of β-thioketones

Tetrahedron, 1997-05, Vol.53 (19), p.6595-6609

1997

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Organic synthesis: beta-ketomacrolide by thermal decomposition/macrocyclization, small-compound libraries by solid-phase analogous synthesis, and approach to carbocycles by dianionic Claisen rearrangement

Chen, Chixu

1996

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Cyclic oligolides via acylketene mediated lactonization: Synthesis and characterization

Tetrahedron letters, 1996-10, Vol.37 (43), p.7683-7686

1996

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the α2δ subunit of voltage gated calcium channels

Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]-pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channels

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology

Expedited SAR study of high-affinity ligands to the α2δ subunit of voltage-gated calcium channels : Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Thermal cycloreversion of 2,2-dimethyl-6 (.omega.-hydroxyalkyl)-4H-1,3-dioxin-4-ones: mono-, di-, and trimeric macrocyclic .beta.-keto lactones by intramolecular trapping of (.omega.-hydroxy)acylketenes

Expedited SAR study of high-affinity ligands to the α 2δ subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Mass Spectrometric Analyses of β-Ketolactone Oligomers, Macrocyclic or Catenane Structures?

Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin Activation/Capture Approach/REACAP Technology

Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin Activation/Capture Approach/REACAP Technology

Solid Phase Synthesis of 1,2-Disubstituted Alkenes: A Novel Alkynyldihydropyridine to Alkenylpyridine Isomerization

Resin activation capture technology: Libraries from stabilized acyl-pyridinium on solid support

Expedited SAR study of high-affinity ligands to the alpha(2)delta subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Synthesis of dihydropyridone scaffolds on solid support: Resin activation/capture approach/REACAP technology

"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis

Solid phase synthesis of 2,4-disubstituted pyridine and tetrahydropyridine derivatives: Resin activation/capture approach/REACAP technology

Resin activation capture technology : Libraries from stabilized acyl-pyridinium on solid support: Special Issue on Polymer Supports for Streamlined Organic Synthesis

Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels

Resin activation capture technology: Libraries from stabilized acyl-pyridinium on solid support

Synthesis and biological evaluation of 6-aryl-6 H -pyrrolo[3,4- d ]pyridazine derivatives as high-affinity ligands of the α 2 δ subunit of voltage-gated calcium channels

Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels

Synthesis and biological evaluation of 6-aryl-6 H -pyrrolo[3,4- d ]pyridazine derivatives: high-affinity ligands to the α 2 δ subunit of voltage gated calcium channels

The solid-phase combinatorial synthesis of β-thioketones

Organic synthesis: beta-ketomacrolide by thermal decomposition/macrocyclization, small-compound libraries by solid-phase analogous synthesis, and approach to carbocycles by dianionic Claisen rearrangement

Cyclic oligolides via acylketene mediated lactonization: Synthesis and characterization

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