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A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Nature communications, 2021-06, Vol.12 (1), p.3907-15, Article 3907

2021

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Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase

The Journal of biological chemistry, 2015-07, Vol.290 (29), p.18124-18133

2015

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The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Nature communications, 2017-01, Vol.8 (1), p.13944-13944, Article 13944

2017

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F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

Nature immunology, 2012-07, Vol.13 (7), p.651

2012

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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

Nature immunology, 2013-05, Vol.14 (5), p.470

2013

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Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Nature communications, 2017-05, Vol.8 (1), p.15203-13, Article 15203

2017

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Natural Products as Targeted Modulators of the Immune System

Journal of immunology research, 2018-01, Vol.2018, p.7862782-2

2018

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The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

The Journal of biological chemistry, 2015-05, Vol.290 (19), p.11843-11852

2015

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Post-translational modification of the interferon-gamma receptor alters its stability and signaling

Biochemical journal, 2017-10, Vol.474 (20), p.3543-3557

2017

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F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

Blood, 2012-03, Vol.119 (13), p.3132-3141

2012

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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in pharmacology, 2022-01, Vol.13, p.828643, Article 828643

2022

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

Redox biology, 2020-05, Vol.32, p.101485, Article 101485

2020

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Targeting F box protein Fbxo3 to control cytokine-driven inflammation

The Journal of immunology (1950), 2013-11, Vol.191 (10), p.5247-5255

2013

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Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

The Journal of experimental medicine, 2016-05, Vol.213 (6), p.1029-1046

2016

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Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O-Palmitoylation to Regulate mRNA Synthesis

The Journal of biological chemistry, 2011-08, Vol.286 (32), p.28019-28025

2011

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Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase

Molecular and Cellular Biology, 2009-06, Vol.29 (11), p.3062-3075

2009

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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

Journal of Immunology Research, 2018, Vol.2018, p.2481418-9

2018

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Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Cell cycle (Georgetown, Tex.), 2012-02, Vol.11 (4), p.721-729

2012

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14-3-3 Binding and Phosphorylation of Neuroglobin during Hypoxia Modulate Six-to-Five Heme Pocket Coordination and Rate of Nitrite Reduction to Nitric Oxide

The Journal of biological chemistry, 2011-12, Vol.286 (49), p.42679-42689

2011

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Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells

Journal of Immunology Research, 2018-01, Vol.2018, p.5604610-8

2018

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E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

Cell reports (Cambridge), 2014-04, Vol.7 (2), p.476-487

2014

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Calmodulin Binds and Stabilizes the Regulatory Enzyme, CTP:Phosphocholine Cytidylyltransferase

The Journal of biological chemistry, 2007-11, Vol.282 (46), p.33494-33506

2007

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The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

Science translational medicine, 2015-07, Vol.7 (295), p.295ra109

2015

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Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

Molecular and Cellular Biology, 2011-05, Vol.31 (9), p.1905-1920

2011

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A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Natural Products as Targeted Modulators of the Immune System

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

Post-translational modification of the interferon-gamma receptor alters its stability and signaling

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

Targeting F box protein Fbxo3 to control cytokine-driven inflammation

Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O-Palmitoylation to Regulate mRNA Synthesis

Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

14-3-3 Binding and Phosphorylation of Neuroglobin during Hypoxia Modulate Six-to-Five Heme Pocket Coordination and Rate of Nitrite Reduction to Nitric Oxide

Cyanidin-3-glucoside Alleviates 4-Hydroxyhexenal-Induced NLRP3 Inflammasome Activation via JNK-c-Jun/AP-1 Pathway in Human Retinal Pigment Epithelial Cells

E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

Calmodulin Binds and Stabilizes the Regulatory Enzyme, CTP:Phosphocholine Cytidylyltransferase

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

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